Astrocytic changes in the hippocampus and functional recovery after cerebral ischemia are facilitated by rehabilitation training
Astrocytic changes in the hippocampus and functional recovery after cerebral ischemia are facilitated by rehabilitation training
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DOI：
10.1016/j.bbr.2006.03.011
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发表时间：
2006-07-15
影响因子：
2.7
通讯作者：
Nguyen, M
中科院分区：
文献类型：
--
作者：
Briones, TL;Woods, J;Nguyen, M
在这项研究中，我们研究是否星形胶质细胞和碱性成纤维细胞生长因子的变化，脑缺血后可以通过康复训练的影响，如果这些变化与功能的改善。雄性成年Wistar大鼠在缺血或假手术后，随机分为两组：复合环境饲养组（EC）和对照组（CON）。康复训练14天后，在水迷宫中测试大鼠。结果显示，在所有缺血动物和假EC大鼠中反应性星形胶质细胞（GFAP）的表达增加，在缺血EC圈养动物中观察到显著的总体增加。观察到的碱性成纤维细胞生长因子（FGF-2）表达模式与GFAR的表达模式有些相似。行为数据显示，即使所有动物随着时间的推移学会执行水迷宫任务，缺血CON大鼠需要更长的时间来学习任务，而所有缺血EC动物的表现与假手术组一样。回归分析表明，增加GFAP是能够解释的缺血EC大鼠在水迷宫中的行为参数的变化，这表明在这组星形胶质细胞的激活可能介导增强功能恢复的一些。最后，脑缺血后星形胶质细胞活化的有利作用可能是由FGF-2介导的。(c)2006 Elsevier B. V.保留所有权利。
In this study we examined whether astrocytic and basic fibroblast growth factor changes after cerebral ischemia can be influenced by rehabilitation training and if these changes are associated with functional improvement. After receiving either ischemia or sham surgery, male adult Wistar rats were assigned to one of two rehabilitation training group: complex environment housing (EC) or paired housing as, controls (CON). Rats were tested in the water maze after 14 days of rehabilitation training. Results showed increased expression of reactive astrocytes (GFAP) in all ischemic animals and in the sham EC rats with a significant overall increased seen in the ischemia EC housed animals. The pattern of basic fibroblast growth factor (FGF-2) expression seen was somewhat similar to that of GFAR Behavioral data showed that even though all animals learned to perform the water maze task over time, the ischemia CON rats took longer to learn the task while all the ischemia EC animals performed as well as the sham groups. Regression analysis showed that increased GFAP was able to explain some of the variances in the behavioral parameters in the water maze of the ischemia EC rats suggesting that the activation of astrocytes in this group probably mediated enhanced functional recovery. Lastly, it is possible that the favorable effect of astrocyte activation after cerebral ischemia was mediated by FGF-2. (c) 2006 Elsevier B.V. All rights reserved.