Cellular Mechanisms of Aortic Aneurysm Formation
Cellular Mechanisms of Aortic Aneurysm Formation
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DOI：
10.1161/circresaha.118.313187
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发表时间：
2019-02-15
影响因子：
20.1
通讯作者：
Taylor, W. Robert
中科院分区：
文献类型：
--
作者：
Quintana, Raymundo Alain;Taylor, W. Robert
主动脉瘤是西方人群中常见的血管疾病，几乎可以累及主动脉的任何部分。腹主动脉瘤比胸主动脉瘤更常见，在美国，每年有超过25000人死于腹主动脉瘤。尽管胸主动脉瘤和腹主动脉瘤具有一些共同的特征，包括大体解剖外观、细胞外基质改变和平滑肌细胞丢失，但它们是不同的疾病。近年来，基因分析的进步，强大的分子工具，以及动物模型的增加，大大提高了我们对主动脉瘤的病理生理学的认识。本文综述了各种提出的细胞机制负责主动脉瘤的形成，并确定未来的研究机会。
Aortic aneurysms are a common vascular disease in Western populations that can involve virtually any portion of the aorta. Abdominal aortic aneurysms are much more common than thoracic aortic aneurysms and combined they account for >25 000 deaths in the United States annually. Although thoracic and abdominal aortic aneurysms share some common characteristics, including the gross anatomic appearance, alterations in extracellular matrix, and loss of smooth muscle cells, they are distinct diseases. In recent years, advances in genetic analysis, robust molecular tools, and increased availability of animal models have greatly enhanced our knowledge of the pathophysiology of aortic aneurysms. This review examines the various proposed cellular mechanisms responsible for aortic aneurysm formation and identifies opportunities for future studies.