Bronchoconstrictor effects of leukotriene C in humans.
Bronchoconstrictor effects of leukotriene C in humans.
复制标题
白三烯 C 对人体的支气管收缩作用。
DOI：
10.1126/science.7063880
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Austen,KF
中科院分区：
文献类型：
--
作者：
Weiss,JW;Drazen,JM;Coles,N;McFaddenJr,ER;Weller,PF;Corey,EJ;Lewis,RA;Austen,KF
最大呼气流速在30%的肺活量以上残气量作为一个指数的气道阻塞比较的影响，白三烯C和组胺气雾剂给药的5个正常人。白三烯C在产生相当于残气量以上30%肺活量时最大呼气流速的减量方面比组胺强600 ~ 9500倍。白三烯C的反应是缓慢的，在发病和延长，让人想起哮喘过敏受试者的气溶胶过敏原挑战的影响。
Maximum expiratory flow rate at 30 percent of vital capacity above residual volume served as an index of airway obstruction in comparing the effects of leukotriene C and histamine administered by aerosol to five normal persons. Leukotriene C was 600 to 9500 times more potent than histamine on a molar basis in producing an equivalent decrement in the maximum expiratory flow rate at 30 percent of vital capacity above residual volume. The leukotriene C response was slow in onset and prolonged, reminiscent of the effects of aerosol allergen challenge in asthmatic allergic subjects.