Prevalence and risk factors for age-related macular degeneration in an adult Japanese population
Prevalence and risk factors for age-related macular degeneration in an adult Japanese population
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DOI：
10.1016/j.ophtha.2007.11.015
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发表时间：
2008-08-01
期刊：
影响因子：
13.7
通讯作者：
Wong, Tien Yin
中科院分区：
文献类型：
--
作者：
Kawasaki, Ryo;Wang, Jie Jin;Wong, Tien Yin
目的：描述年龄相关性黄斑变性（AMD）在日本人群中的患病率和危险因素，并与来自白色人群的数据进行比较。设计：基于人群的横断面流行病学研究。参与者：来自日本Funagata的35岁或35岁以上的日本人群。方法：Funagata研究是一项基于人群的研究，纳入了来自日本Funagata的1758名（43%的合格）35岁或以上的日本人。在2000年至2002年，1625例（92.4%）参与者有一只眼睛的非散瞳眼底照片，其质量足以对AMD病变进行分级，使用威斯康星州方案。计算与蓝山眼科研究（BMES）人群相比的标准化患病率、比值比（OR）和95%置信区间（CI）。结果：在1625名参与者中，早期AMD和晚期AMD分别占3.5%和0.5%。右眼的标准化早期AMD患病率为4.1%，与BMES的4.4%的相应患病率相似。在BMES中，男性右眼晚期AMD的年龄标准化患病率分别为1.1%和1.2%;女性相应的患病率分别为0.3%和2.1%。增加年龄（每10年;性别调整的OR，2.27; 95%CI，1.10-4.67）和目前吸烟（年龄和性别调整的OR，5.03; 95%CI，1.00-25.47）与晚期AMD.Conclusions：在这个日本人口中，早期AMD的患病率是相似的白人在BMES。虽然晚期AMD患病率在日本女性中较低，但在日本男性中与白人相似。这可能是由于日本男性吸烟者的比例相当高。吸烟和年龄增长是与晚期AMD相关的2个主要因素。
Objective: To describe the prevalence and risk factors for age-related macular degeneration (AMD) in a Japanese population and to compare these with data from a white population.Design: Population-based cross-sectional epidemiologic study.Participants: A population-based sample of Japanese persons 35 years or older from Funagata, Japan.Methods: The Funagata study is a population-based study of 1758 (43% of eligible) Japanese persons 35 years or older from Funagata, Japan. In 2000 to 2002, 1625 (92.4%) participants had a nonmydriatic fundus photograph of one eye with sufficient quality for grading of AMD lesions, using the Wisconsin protocol. Age-standardized prevalence rates compared with the Blue Mountains Eye Study (BMES) population, odds ratios (ORs), and 95% confidence intervals (CIs) were calculated. Risk factors were assessed by logistic regression.Main Outcome Measures: Early and late AMD.Results: Of 1625 participants, early AMD and late AMD were present in 3.5% and 0.5%, respectively. Age-standardized early AMD prevalence in right eyes was 4.1%, similar to the corresponding prevalence of 4.4% in the BMES. For men, age-standardized prevalences of late AMD in right eyes were 1.1% and 1.2% in the BMES; for women, the corresponding prevalences were 0.3% and 2.1%, respectively. Increasing age (per 10 years; gender-adjusted OR, 2.27; 95% CI, 1.10-4.67) and current cigarette smoking (age- and gender-adjusted OR, 5.03; 95% CI, 1.00-25.47) were associated with late AMD.Conclusions: In this Japanese population, prevalence of early AMD was similar to that for whites in the BMES. Although the late AMD prevalence was lower in Japanese women, in Japanese men it was similar to that in whites. This could have resulted from the substantially high proportion of Japanese men who are smokers. Cigarette smoking and increasing age were the 2 principal factors found associated with late AMD.