Interplay of Proximal Flow Confluence and Distal Flow Divergence in Patient-Specific Vertebrobasilar System.
Interplay of Proximal Flow Confluence and Distal Flow Divergence in Patient-Specific Vertebrobasilar System.
复制标题
患者特定椎基底系统中近端血流汇合和远端血流发散的相互作用。
DOI：
10.1371/journal.pone.0159836
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Huo Y
中科院分区：
文献类型：
--
作者：
Yin X;Huang X;Feng Y;Tan W;Liu H;Huo Y
大约四分之一的缺血性中风涉及椎基底动脉系统，包括上游血流合流和下游血流分流。需要对患者进行特定的血液动力学分析来了解后循环。本研究的目的是根据计算机断层血管造影图像确定椎基底动脉系统中血流动力学参数的分布。在这里，上游血流合流和下游血流散度的相互作用被假设为椎基底动脉系统血流动力学分布的决定因素。计算流体动力学模型用于计算特定患者椎基底动脉模型的流场（n = 6）。入口和出口边界条件分别为主动脉压波形和流动阻力。总出口面积减少50%，低时间平均壁剪应力表面积比（即TAWSS≤4 dynes/cm2）增加10倍。这项研究增强了我们对后循环与动脉粥样硬化斑块发生率的认识。
Approximately one-quarter of ischemic strokes involve the vertebrobasilar arterial system that includes the upstream flow confluence and downstream flow divergence. A patient-specific hemodynamic analysis is needed to understand the posterior circulation. The objective of this study is to determine the distribution of hemodynamic parameters in the vertebrobasilar system, based on computer tomography angiography images. Here, the interplay of upstream flow confluence and downstream flow divergence was hypothesized to be a determinant factor for the hemodynamic distribution in the vertebrobasilar system. A computational fluid dynamics model was used to compute the flow fields in patient-specific vertebrobasilar models (n = 6). The inlet and outlet boundary conditions were the aortic pressure waveform and flow resistances, respectively. A 50% reduction of total outlet area was found to induce a ten-fold increase in surface area ratio of low time-averaged wall shear stress (i.e., TAWSS ≤ 4 dynes/cm2). This study enhances our understanding of the posterior circulation associated with the incidence of atherosclerotic plaques.