Oxidative phenol-arene and phenol-phenol cross-coupling using periodic acid
Oxidative phenol-arene and phenol-phenol cross-coupling using periodic acid
复制标题
DOI：
10.1016/j.tet.2019.02.021
复制
发表时间：
2019-03-29
期刊：
影响因子：
2.1
通讯作者：
Zhang, Qiang
中科院分区：
文献类型：
--
作者：
Gao, Peng-Cheng;Chen, Huan;Zhang, Qiang
报道了一种简单的，不含金属的H5 IO 6不对称联芳偶联反应。H5 IO 6在苯酚-芳烃、苯酚-苯酚和苯酚-萘酚化合物的氧化交叉偶联中具有新的应用。在这项工作中，大多数耦合在室温下30分钟内完成。在HFIP中仅使用0.5当量的H5 IO 6方便地获得30种偶联产物。的转换发生的机制提出。(C)2019爱思唯尔有限公司版权所有。
A simple, metal-free protocol for unsymmetrical biaryl coupling using H5IO6 is reported. H5IO6 was evaluated for a novel application in the oxidative cross-coupling of phenol-arene, phenol-phenol, and phenol-naphthol compounds. In this work, most of the couplings were completed within 30 min at ambient temperature. 30 coupling products were conveniently obtained using only 0.5 equivalent of H5IO6 in HFIP. A mechanism by which the transformation occurs is proposed. (C) 2019 Elsevier Ltd. All rights reserved.