Thermal response of multi-layer UV crosslinked PEGDA hydrogels
Thermal response of multi-layer UV crosslinked PEGDA hydrogels
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DOI：
10.1016/j.polymdegradstab.2021.109805
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发表时间：
2022-01-07
影响因子：
5.9
通讯作者：
Aria, Adrianus Indrat
中科院分区：
文献类型：
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作者：
Khalili, Mohammad Hakim;Afsar, Ashfaq;Aria, Adrianus Indrat
聚乙二醇二丙烯酸酯 (PEGDA) 水凝胶广泛用于组织工程的各种应用。在本研究中，通过重量法和体积法研究了多层PEGDA水凝胶在温控环境（8、20、37和45℃）的各种条件下的热响应。这些多层水凝胶是使用计算机控制的投影光刻技术生产的，并与通过本体光交联制造的整体水凝胶进行了比较。据观察，多层PEGDA水凝胶的体积在8℃下增加至约10％，而在37℃和45℃下储存时体积分别减少8％和12％。 PEGDA水凝胶还表现出各向异性特征，其中轴向尺寸变化比横向尺寸高约43%。这一发现对于 PEGDA 水凝胶的设计和制造至关重要，以补偿不同温度下应用过程中的轴向和横向体积变化。 (C) 2021 Elsevier Ltd. 保留所有权利。
Poly(ethylene glycol) diacrylate (PEGDA) hydrogels are ubiquitously used in a wide variety of applications in tissue engineering. In this study, the thermal response of multi-layered PEGDA hydrogels was investigated under various conditions of the temperature-controlled environments (8, 20, 37, and 45 degrees C) through gravimetric and volumetric methods. These multi-layered hydrogels were produced using a computer-controlled projection lithography and compared to the monolithic hydrogels fabricated through bulk photo-crosslinking. It was observed that the volume of multi-layered PEGDA hydrogels increased to about 10% at a temperature of 8 degrees C, while their volume decreased by 8% and 12% when stored at 37 degrees C and 45 degrees C, respectively. PEGDA hydrogel also showed an anisotropic characteristic where the axial dimensional change was about 43% higher than the lateral dimension. This finding is critical to inform the design and fabrication of PEGDA hydrogels to compensate for the axial and lateral volume changes during the application at different temperatures. (C) 2021 Elsevier Ltd. All rights reserved.