Papillary thyroid cancer
Papillary thyroid cancer
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DOI：
10.1016/j.soc.2006.05.010
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发表时间：
2006-07-01
影响因子：
1.9
通讯作者：
Udelsman, Robert
中科院分区：
文献类型：
--
作者：
Sosa, Julie Ann;Udelsman, Robert
甲状腺乳头状癌 (PTC) 很常见，但很少导致疾病特异性死亡。由于超声成像的增强和对较小甲状腺结节更积极的监测，该病越来越多地在亚临床阶段被诊断出来。超声引导下的细针抽吸是诊断的金标准。尽管关于 PTC 的适当手术治疗仍存在争议，但考虑到该疾病频繁的多中心性和转移，通常需要进行全甲状腺切除术，这反过来又需要辅助放射性碘治疗和仔细监测。增强的预后分类可以更好地指导初始手术治疗、标准化监测并降低复发和持续性疾病的风险。研究工作应集中于 PTC 的遗传和分子基础，因为这些将有助于识别其他预后因素和新疗法的潜在靶点。
Papillary thyroid carcinoma (PTC) is common, although it rarely results in disease-specific mortality. It is being diagnosed increasingly in the subclinical phase as a result of enhanced ultrasound imaging and more aggressive surveillance of smaller thyroid nodules. Ultrasound-guided fine-needle aspiration is the gold standard for diagnosis. Although controversy continues about the appropriate surgical management of PTC, total thyroidectomy is usually indicated, given the frequent multicentricity and metastases of the disease, which in turn, necessitates adjuvant radioactive iodine treatment and careful surveillance. An enhanced prognostic classification could better guide initial surgical therapy, standardize surveillance, and reduce the risk of recurrent and persistent disease. Research efforts should focus on the genetic and molecular underpinnings of PTC, as these would facilitate the identification of additional prognostic factors and potential targets for novel therapies.