In-situ extraction and separation of salvianolic acid B from Salvia miltiorrhiza Bunge by integrated expanded bed adsorption
In-situ extraction and separation of salvianolic acid B from Salvia miltiorrhiza Bunge by integrated expanded bed adsorption
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集成膨胀床吸附原位提取分离丹参中丹酚酸B
DOI：
10.1016/j.seppur.2011.06.039
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发表时间：
2011-08-18
影响因子：
8.6
通讯作者：
Hu, Ping
中科院分区：
文献类型：
--
作者：
Zhang, Min;Yang, Huihua;Hu, Ping
本文介绍了一种从丹参中原位回收丹酚酸B的一体化膨胀床萃取分离方法。在动态萃取柱中提取25g中草药3h，同时将靶标吸收到扩展床柱上而不进行任何进一步处理。然后，用1床体积的水和5床体积的50%(v/v)乙醇水溶液以2.4BV/h的流速洗脱膨胀床柱，得到丹酚酸1438.8 mg，纯度为55.7%，回收率为88.0%。以纯度、回收率、过程处理量、过程效率、过程环境影响和一般过程评价六个评价参数作为不同方法的评价指标。结果表明，该方法是从丹参药材中提取丹酚酸B的一种很有前途的工艺。(C)2011爱思唯尔B.V.保留所有权利。
This article describes the development of an integrated expanded bed extraction and separation method for in-situ recovery of salvianolic acid B from Salvia miltiorrhiza Bunge. Twenty-five grams of the herb was extracted in a dynamic extraction column for 3 h, while the target was simultaneously absorbed onto an expanded bed column without any further processing. Then, the expanded bed column was eluted with 1 bed volume (BV) of water and 5 BVs of 50% (v/v) ethanol aqueous solution with a flow rate of 2.4 BV/h. From this, 1438.8 mg of salvianolic acids, containing 55.7% of pure salvianolic acid B, was harvested with an 88.0% recovery. Six evaluation parameters - purity, recovery, process throughput, process efficiency, process environmental impact and general process evaluation - were used as indices for evaluation of different methods. The results indicate that the in-situ method we have developed is a promising process for the recovery of salvianolic acid B from the herb of S. miltiorrhiza Bunge. (C) 2011 Elsevier B.V. All rights reserved.