Effect of prophylactic treatment on suicide risk in patients with major affective disorders - Data from a randomized prospective trial
Effect of prophylactic treatment on suicide risk in patients with major affective disorders - Data from a randomized prospective trial
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DOI：
10.1055/s-2007-979553
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发表时间：
1996-05-01
影响因子：
4.3
通讯作者：
Greil, W
中科院分区：
文献类型：
--
作者：
ThiesFlechtner, K;MullerOerlinghausen, B;Greil, W
为了比较锂与卡马西平和阿米替林的效果，我们在随机前瞻性长期MAP研究中分析了自杀行为（N = 378；持续时间2.5年）。在9例自杀和5例企图自杀中，没有一例发生在锂治疗期间。研究结果支持了这样一种观点，即锂具有特定的抗自杀作用，而不仅仅是它的预防作用。
Recent findings have indicated that lithium treatment markedly reduces suicide risk in major affective disorders, To compare the effect of lithium with carbamazepine and amitriptyline, suicidal behavior was analyzed during the randomized prospective long-term MAP study (N = 378; duration 2.5 years), Of the nine suicides and five attempted suicides, none took place during lithium treatment. The findings support the view that lithium has a specific antisuicidal effect over and above its prophylactic benefit.