Expression of a human multidrug resistance cDNA (MDR1) in the bone marrow of transgenic mice: resistance to daunomycin-induced leukopenia
Expression of a human multidrug resistance cDNA (MDR1) in the bone marrow of transgenic mice: resistance to daunomycin-induced leukopenia
复制标题
转基因小鼠骨髓中人类多药耐药 cDNA (MDR1) 的表达：对道诺霉素诱导的白细胞减少症的抵抗
DOI：
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复制
发表时间：
1989
影响因子：
5.3
通讯作者：
G. Merlino
中科院分区：
文献类型：
--
作者：
H. Galski;M. Sullivan;M. Willingham;K. Chin;M. Gottesman;I. Pastan;G. Merlino
The human multidrug resistance gene (MDR1) encodes a drug efflux pump glycoprotein (P-glycoprotein) responsible for resistance to multiple cytotoxic drugs. A plasmid carrying a human MDR1 cDNA under the control of a chicken beta-actin promoter was used to generate transgenic mice in which the transgene was mainly expressed in bone marrow and spleen. Immunofluorescence localization studies showed that P-glycoprotein was present on bone marrow cells. Furthermore, leukocyte counts of the transgenic mice treated with daunomycin did not fall, indicating that their bone marrow was resistant to the cytotoxic effect of the drug. Since bone marrow suppression is a major limitation to chemotherapy, these transgenic mice should serve as a model to determine whether higher doses of drugs can cure previously unresponsive cancers.
DOI：
10.1073/pnas.85.3.836
发表时间：
1988-02-01
影响因子：
11.1
作者：
BRINSTER, RL;ALLEN, JM;PALMITER, RD
通讯作者：
PALMITER, RD
哺乳动物细胞中与多药耐药性相关的基因的扩增和表达。
DOI：
10.1126/science.2421411
发表时间：
1986
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Scotto,KW;Biedler,JL;Melera,PW
通讯作者：
Melera,PW