Advances in understanding vertebrate nephrogenesis.
Advances in understanding vertebrate nephrogenesis.
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DOI：
10.1080/21688370.2020.1832844
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发表时间：
2020-10-01
期刊：
影响因子：
3.1
通讯作者：
Wingert RA
中科院分区：
文献类型：
--
作者：
Chambers JM;Wingert RA
肾脏是一个复杂的器官，除了其他功能外，它还执行血液过滤和液体动态平衡等基本功能。近年来，我们对控制肾脏形成的机制的认识取得了重大进展。在这里，我们提供了脊椎动物肾脏发育的概述，重点是肾脏发生，即产生肾脏上皮化功能单位的过程。这些步骤从中间中胚层规格开始，一直进行到终末分化的肾单位细胞，中间有许多详细的阶段。在这些过程中，具有适当细胞屏障的肾单位结构的建立是至关重要的。不断努力获得对肾脏发生的进一步了解，最终可以更好地理解和治疗先天性肾脏和尿路畸形(CAKUT)等发育性疾病。
The kidney is a complex organ that performs essential functions such as blood filtration and fluid homeostasis, among others. Recent years have heralded significant advancements in our knowledge of the mechanisms that control kidney formation. Here, we provide an overview of vertebrate renal development with a focus on nephrogenesis, the process of generating the epithelialized functional units of the kidney. These steps begin with intermediate mesoderm specification and proceed all the way to the terminally differentiated nephron cell, with many detailed stages in between. The establishment of nephron architecture with proper cellular barriers is vital throughout these processes. Continuously striving to gain further insights into nephrogenesis can ultimately lead to a better understanding and potential treatments for developmental maladies such as Congenital Anomalies of the Kidney and Urinary Tract (CAKUT).