Periodontitis and Systemic Disease: Association or Causality?
Periodontitis and Systemic Disease: Association or Causality?
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DOI：
10.1007/s40496-017-0121-7
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发表时间：
2017
影响因子：
--
通讯作者：
Linden GJ
中科院分区：
文献类型：
--
作者：
Winning L;Linden GJ
目的是评估糖尿病、代谢综合征（MetS）和肥胖影响牙周炎进展的最新证据。使用Embase，Medline和Web of Science进行了2014年至2016年期间发表的人类流行病学研究的电子检索。少数的前瞻性研究和系统评价，一般提供进一步支持的假设，糖尿病，代谢综合征和肥胖症会对牙周状况产生不利影响。在解释糖尿病、代谢综合征、肥胖和牙周病之间的关系时，混淆仍然是最具挑战性的问题。最近的研究应用孟德尔随机方法得出结论，肥胖和牙周炎之间的关联是混淆的，并质疑肥胖在因果关系中的作用。需要进一步研究来评估因果关系问题。
The aim was to assess recent evidence that diabetes, metabolic syndrome (MetS) and obesity impact the progression of periodontitis. Electronic searches using Embase, Medline, and Web of Science were carried out for epidemiological studies on humans, published between 2014 and 2016. A small number of prospective studies and systematic reviews were identified that in general provide further support for the hypothesis that diabetes, metabolic syndrome and obesity can adversely affect the periodontal condition. Confounding remains the most challenging issue in the interpretation of the associations found between diabetes, MetS, obesity and periodontal disease. Recent research applying a Mendelian randomisation approach concluded that the association between obesity and periodontitis is confounded and questioned a role for obesity in causation. Further studies are warranted to assess the issue of causality.