Relationship of DAT1 and adult ADHD to task-positive and task-negative working memory networks.
Relationship of DAT1 and adult ADHD to task-positive and task-negative working memory networks.
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DOI：
10.1016/j.pscychresns.2011.01.006
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发表时间：
2011-07-30
影响因子：
11.3
通讯作者：
Seidman L
中科院分区：
文献类型：
--
作者：
Brown AB;Biederman J;Valera E;Makris N;Doyle A;Whitfield-Gabrieli S;Mick E;Spencer T;Faraone S;Seidman L
工作记忆、默认模式网络(DMN)和多巴胺转运体的改变都被认为是注意力缺陷多动/障碍(ADHD)的内在表型。尽管有证据表明这些系统是相互关联的，但它们之间的关系从未在ADHD的背景下进行过研究。为了了解任务-积极和任务-消极网络在DAT1和诊断之间的潜在中介作用，我们测试了53名ADHD成人和38名对照受试者在工作记忆任务中，基因和诊断对BOLD信号正负变化区域的影响。我们还研究了这些反应与ADHD症状的关系。我们的结果得到了四个主要发现：1)9R与成人ADHD有关，2)DAT1边缘与左侧前额叶内侧的任务相关抑制有关，3)在背侧扣带回的边缘基因×诊断交互作用，以及4)DMN抑制与ADHD症状相关。这些发现重复了9R等位基因与成人ADHD的关联。此外，我们还发现，DMN抑制可能与ADHD的DAT1和注意力不集中的严重程度有关。因此，DMN可能是DAT1效应的靶点，并且位于ADHD基因和注意力不集中之间的路径上。
Alterations in working memory, default-mode network (DMN), and dopamine transporter have all been proposed as endophenotypes for Attention-Deficit Hyperactivity/Disorder (ADHD). Despite evidence that these systems are interrelated, their relationship to each other has never been studied in the context of ADHD. In order to understand the potential mediating effects of task-positive and task-negative networks between DAT1 and diagnosis, we tested effects of genotype and diagnosis on regions of positive and negative BOLD signal change (as measured with fMRI) in 53 adults with ADHD and 38 control subjects during a working memory task. We also examined the relationship of these responses to ADHD symptoms. Our results yielded four principal findings: 1) association of 9R with adult ADHD, 2) marginal DAT1 association with task-related suppression in left medial PFC, 3) marginal genotype × diagnosis interaction in the dorsal anterior cingulate cortex, and 4) correlation of DMN suppression to ADHD symptoms. These findings replicate the association of the 9R allele with adult ADHD. Further, we show that DMN suppression is likely linked to DAT1 and to severity of inattention in ADHD. DMN may therefore be a target of DAT1 effects, and lie on the path between the gene and inattention in ADHD.
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影响因子：
5.9
作者：
Faraone, SV;Biederman, J;Monuteaux, MC
通讯作者：
Monuteaux, MC
DOI：
10.1523/jneurosci.4858-08.2009
发表时间：
2009-01-28
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bertolino A;Fazio L;Di Giorgio A;Blasi G;Romano R;Taurisano P;Caforio G;Sinibaldi L;Ursini G;Popolizio T;Tirotta E;Papp A;Dallapiccola B;Borrelli E;Sadee W
通讯作者：
Sadee W
影响因子：
4.8
作者：
Cohen, J D;Forman, S D;Noll, D C
通讯作者：
Noll, D C
影响因子：
10.6
作者：
Bertolino, Alessandro;Di Giorgio, Annabella;Dallapiccola, Bruno
通讯作者：
Dallapiccola, Bruno
DOI：
10.1002/ajmg.b.30572
发表时间：
2007-12-05
影响因子：
2.8
作者：
Brookes, Keeley J.;Neale, Benjamin M.;D'Souza, Ursula M.
通讯作者：
D'Souza, Ursula M.