Local circuit amplification of spatial selectivity in the hippocampus
Local circuit amplification of spatial selectivity in the hippocampus
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DOI：
10.1038/s41586-021-04169-9
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发表时间：
2021-12-01
期刊：
影响因子：
64.8
通讯作者：
Losonczy, Attila
中科院分区：
文献类型：
--
作者：
Geiller, Tristan;Sadeh, Sadra;Losonczy, Attila
局部电路结构促进了大脑皮层功能选择性的出现(1)。在海马区，尚不清楚特定连接基序(2)支持的局部计算是否调节锥体细胞(3)的空间感受野。在这里，我们开发了一种体内电穿孔方法，用于单突触逆行追踪(4)和单细胞分辨率的光遗传学操作，以询问定位细胞与其微电路在导航过程中的动态相互作用。我们在CA1中发现了一种局部电路机制，通过该机制，单个位置单元的空间调谐可以传播到它所属的功能递归的子网络(5)。单个神经元中位置场的出现导致其突触前中间神经元的子集产生反向选择性，并在该位置招募功能耦合的位置细胞。因此，单个CA1神经元的空间选择性通过局部电路可塑性被放大，从而使得有效的多神经元表征能够在不降低前馈输入结构的情况下灵活地局部缩放环境特征。
Local circuit architecture facilitates the emergence of feature selectivity in the cerebral cortex(1). In the hippocampus, it remains unknown whether local computations supported by specific connectivity motifs(2) regulate the spatial receptive fields of pyramidal cells(3). Here we developed an in vivo electroporation method for monosynaptic retrograde tracing(4) and optogenetics manipulation at single-cell resolution to interrogate the dynamic interaction of place cells with their microcircuitry during navigation. We found a local circuit mechanism in CA1 whereby the spatial tuning of an individual place cell can propagate to a functionally recurrent subnetwork(5) to which it belongs. The emergence of place fields in individual neurons led to the development of inverse selectivity in a subset of their presynaptic interneurons, and recruited functionally coupled place cells at that location. Thus, the spatial selectivity of single CA1 neurons is amplified through local circuit plasticity to enable effective multi-neuronal representations that can flexibly scale environmental features locally without degrading the feedforward input structure.