Natural killer cell-based immunotherapeutic strategies
Natural killer cell-based immunotherapeutic strategies
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DOI：
10.1080/14653240510018000
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发表时间：
2005-03-01
期刊：
影响因子：
4.5
通讯作者：
Klingemann, HG
中科院分区：
文献类型：
--
作者：
Klingemann, HG
直到最近，自然杀伤(NK)细胞才走出T细胞的阴影，被考虑用于恶性疾病的细胞治疗。NK细胞上与靶细胞上的HLA分子相互作用的特定受体的发现促进了这一进化，同时也发现了特定的激活受体。由于NK细胞仅占血液中淋巴细胞总数的10%左右，因此如果要将NK细胞用于临床，分离和浓缩是重要的步骤。这在同种异体NK细胞输注的环境中尤其值得考虑，在这种情况下，污染的T细胞可能会诱发移植物抗宿主疾病。这篇综述将描述NK细胞识别靶细胞的要求，它们的体外扩增和潜在的治疗应用。
Not until recently have Natural killer (NK) cells stepped out of the shadow of T-cells to be considered for cellular therapy of malignant diseases. This evolution has been facilitated by the discovery of specific receptors on NK cells that interact with HLA molecules on target cells but also the discovery of specific activating receptors. Since NK cells represent only about 10% of the lymphocyte population in blood, separation and enrichment are important steps if NK cells are to be used clinically. This is of particular consideration in the setting of allogeneic NK cell infusion where contaminating T-cells could potentially induce graft versus host disease. This review will describe the requirements for NK cells to recognize target cells, their ex vivo expansion and potential therapeutic applications.