Prediction of Post-Concussive Behavioral Changes in a Rodent Model Based on Head Rotational Acceleration Characteristics.
Prediction of Post-Concussive Behavioral Changes in a Rodent Model Based on Head Rotational Acceleration Characteristics.
复制标题
基于头部旋转加速度特征的啮齿动物模型中脑震荡后行为变化的预测。
DOI：
10.1007/s10439-016-1647-x
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发表时间：
2016
影响因子：
3.8
通讯作者：
Pintar,FrankA
中科院分区：
文献类型：
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作者：
Stemper,BrianD;Shah,AlokS;Chiariello,Rachel;Olsen,ChristopherM;Budde,MatthewD;Glavaski-Joksimovic,Aleksandra;McCrea,Michael;Kurpad,ShekarN;Pintar,FrankA
量化对脑震荡的损伤耐受性是复杂的，因为损伤后生理和行为变化的类型、严重程度和时间过程的可变性。目前的研究概述了大鼠旋转加速度诱导脑震荡后行为指标的急性和慢性变化。威斯康星州医学院（MCW）旋转损伤模型独立控制旋转加速度脉冲的幅度和持续时间。增加旋转加速度幅度产生更长的恢复时间，这在本研究和我们以前的工作中被用来评估急性损伤的严重程度。然而，较长时间的旋转加速度产生的情绪变化，使用高架十字迷宫测量。认知缺陷在Morris水迷宫评估中大部分不明显，可能是由于本研究中纳入的旋转加速度脉冲的严重程度较低。在急性和慢性评估之间的情绪变化，在某些情况下，严重程度增加，在其他逆转极性。这些研究结果强调了量化脑震荡损伤耐受性的复杂性，并表明需要将旋转加速度幅度和持续时间纳入拟议的损伤耐受性指标。旋转速度本身并不是脑震荡后急性行为变化幅度或类型的强有力预测因子，尽管使用多变量分析将其与旋转加速度幅度相结合是急性恢复时间和一些慢性情绪型行为变化的最强预测因子。
Quantifying injury tolerance for concussion is complicated by variability in the type, severity, and time course of post-injury physiological and behavioral changes. The current study outlined acute and chronic changes in behavioral metrics following rotational acceleration-induced concussion in rats. The Medical College of Wisconsin (MCW) rotational injury model independently controlled magnitude and duration of the rotational acceleration pulse. Increasing rotational acceleration magnitude produced longer recovery times, which were used in this study and our prior work as an assessment of acute injury severity. However, longer duration rotational accelerations produced changes in emotionality as measured using the elevated plus maze. Cognitive deficits were for the most part not apparent in the Morris water maze assessment, possibly due to the lower severity of rotational acceleration pulses incorporated in this study. Changes in emotionality evolved between acute and chronic assessments, in some cases increasing in severity and in others reversing polarity. These findings highlight the complexity of quantifying injury tolerance for concussion and demonstrate a need to incorporate rotational acceleration magnitude and duration in proposed injury tolerance metrics. Rotational velocity on its own was not a strong predictor of the magnitude or type of acute behavioral changes following concussion, although its combination with rotational acceleration magnitude using multivariate analysis was the strongest predictor for acute recovery time and some chronic emotional-type behavioral changes.