Use of ion mobility mass spectrometry and a collision cross-section algorithm to study an organometallic ruthenium anticancer complex and its adducts with a DNA oligonucleotide.
Use of ion mobility mass spectrometry and a collision cross-section algorithm to study an organometallic ruthenium anticancer complex and its adducts with a DNA oligonucleotide.
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使用离子淌度质谱和碰撞截面算法研究有机金属钌抗癌复合物及其与 DNA 寡核苷酸的加合物。
DOI：
10.1002/rcm.4285
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
P. Sadler
中科院分区：
文献类型：
--
作者：
Jonathan P. Williams;Julie Ann Lough;I. Campuzano;K. Richardson;P. Sadler
我们报告了一个增强的算法的发展，结合行波离子迁移率质谱技术和它的优化和评价，通过分析的有机钌抗癌配合物[（eta 6-联苯基）Ru（II）（en）Cl]+的碰撞截面的计算。实验确定的和理论确定的复杂的碰撞截面和它的主要产物离子通过碰撞诱导解离形成之间获得了极好的协议。碰撞截面也实验确定的加合物的这种钌络合物与单链寡核苷酸六聚体d（CACGTG）。离子迁移率串联质谱测量允许钌的寡核苷酸上的结合位点被确定。
We report the development of an enhanced algorithm for the calculation of collision cross-sections in combination with Travelling-Wave ion mobility mass spectrometry technology and its optimisation and evaluation through the analysis of an organoruthenium anticancer complex [(eta6-biphenyl)Ru(II)(en)Cl]+. Excellent agreement was obtained between the experimentally determined and theoretically determined collision cross-sections of the complex and its major product ion formed via collision-induced dissociation. Collision cross-sections were also experimentally determined for adducts of this ruthenium complex with the single-stranded oligonucleotide hexamer d(CACGTG). Ion mobility tandem mass spectrometry measurements have allowed the binding sites for ruthenium on the oligonucleotide to be determined.
影响因子：
2.9
作者：
Shvartsburg, Alexandre A.;Mashkevich, Stefan V.;Smith, Richard D.
通讯作者：
Smith, Richard D.
影响因子：
15
作者：
Chen, HM;Parkinson, JA;Sadler, PJ
通讯作者：
Sadler, PJ