A microtomographic system for the nondestructive evaluation of bone architecture
A microtomographic system for the nondestructive evaluation of bone architecture
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DOI：
10.1007/s002239900006
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发表时间：
1996-01-01
影响因子：
4.2
通讯作者：
Muller, R
中科院分区：
文献类型：
--
作者：
Ruegsegger, P;Koller, B;Muller, R
显微断层扫描（微型计算机断层扫描，mu-CT）是一种对骨小梁进行成像和量化的方法。它有能力解决骨小梁结构对骨力学性能的作用，并研究骨小梁重塑。在这项工作中所描述的系统是基于一个紧凑的扇束型断层扫描，可以在螺旋扫描或多层模式。使用具有微焦点的X射线管作为源，CCD阵列作为检测器。可以测量直径从几毫米到最大14 mm的样品，通常测量直径为8 mm且长度约为10 mm的骨活检。空间分辨率为28 μ m。同时，感兴趣体积包含4 × 4 × 4 mm（3），并以14 × 14 × 14 μ m（3）体素表示。3D体视学指标是根据组织形态计量学中使用的标准定义提取的。三角形表面表示的影响与扩展的行军立方体算法，并形成了一个方便的基础有限元分析。显微断层摄影测量可用于“校准”体内低剂量、低分辨率图像，以及非破坏性评估未经处理的手术骨活检标本。这些样本保持完整，用于机械或组织学试验。
Microtomography (micro-computed-tomography, mu-CT) is a method to image and quantify trabecular bone. It has the capability to address the role of trabecular architecture on the mechanical properties of bone and to study trabecular bone remodeling. The system described in this work is based on a compact fan-beam type tomograph that can work in spiral scanning or multislice mode. An X-ray tube with a microfocus is used as a source, a CCD-array as a detector. Samples with diameters from a few millimeters to a maximum of 14 mm can be measured, typically, bone biopsies with a diameter of 8 mm and a length of approximately 10 mm are measured. Spatial resolution is 28 mu m. Usuary the volume of interest contains 4 x 4 x 4 mm(3) and is represented in 14 x 14 x 14 mu m(3) voxels. 3D stereological indices are extracted according to the standard definitions used in histomorphometry. Triangular surface representation is effected with an extended marching cube algorithm and forms a convenient basis for finite element analysis. Microtomographic measurements may be employed to ''calibrate'' lower-dose, lower-resolution images in vivo as well as to nondestructively assess unprocessed surgical bone biopsy specimens. These specimens remain intact for mechanical or histological testing.