Occurrence of ankylosing spondylitis in a nationwide series of twins.
Occurrence of ankylosing spondylitis in a nationwide series of twins.
复制标题
全国双胞胎系列中强直性脊柱炎的发生。
作者：
P. Järvinen
目标
旨在获取基于人群的双胞胎系列中强直性脊柱炎 (AS) 一致率的信息。
方法
AS 病例是通过基于人口的芬兰双胞胎队列和全国全额报销药物登记处的记录联系来确定的。进行临床检查以确定 AS 的一致性。
结果
有 6 对同卵 (MZ) 对和 20 对双卵 (DZ) 对，其中至少 1 名成员受到 AS 影响。 3 个 MZ 对和 3 个 DZ 对对于该疾病是一致的。所有受影响的受试者均为 HLA-B27 阳性。同卵双胞胎中的配对一致性率为 50%，HLA-B27 阳性同卵双胞胎中的配对一致性率为 20%（95% 置信区间分别为 11.8-88.2% 和 4.3%-48.1%）。
结论
这些结果表明 AS 疾病的表达很大程度上但不完全是基于遗传的，B27 以外的一个或多个基因可能发挥了作用。
OBJECTIVE
To obtain information on the rate of concordance for ankylosing spondylitis (AS) in a population-based series of twins.
METHODS
AS cases were identified by record linkage of the population-based Finnish Twin Cohort and the nationwide registry for fully reimbursed medications. A clinical examination was performed to establish concordance for AS.
RESULTS
There were 6 monozygotic (MZ) pairs and 20 dizygotic (DZ) pairs with at least 1 member affected by AS. Three MZ pairs and 3 DZ pairs were concordant for the disease. All affected subjects were HLA-B27 positive. The pairwise concordance rate was 50% in MZ twins and 20% in HLA-B27 positive DZ twins (95% confidence intervals 11.8-88.2% and 4.3%-48.1%, respectively).
CONCLUSION
These results indicate that AS disease expression is largely, but not entirely, genetically based, with a gene or genes other than B27 probably playing a role.
影响因子：
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作者：
ROBINSON, WP;VANDERLINDEN, SM;THOMSON, G
通讯作者：
THOMSON, G