The effect of miRNA and autophagy on colorectal cancer.
The effect of miRNA and autophagy on colorectal cancer.
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DOI：
10.1111/cpr.12900
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发表时间：
2020-10
影响因子：
8.5
通讯作者：
Zhu W
中科院分区：
文献类型：
--
作者：
Long J;He Q;Yin Y;Lei X;Li Z;Zhu W
结直肠癌（Colorectal cancer， CRC）因其复发率和转移率高、早期诊断率低、治疗效果差而备受关注。目前，各种研究表明，自噬与结直肠癌的发生和发展密切相关。自噬是生物进化过程中溶酶体参与的高度胞质分解代谢过程。细胞通过自噬降解蛋白质和受损细胞器，实现物质循环，维持细胞稳态。此外，microrna是自噬的关键调控因子，其介导的转录和转录后水平调控在结直肠癌细胞的自噬中起着重要作用。本文综述了近年来自噬及相关microrna在影响结直肠癌发生进展中的研究进展，为结直肠癌治疗策略的研究提供了新的视角。mirna与结直肠癌自噬的调控关系。自噬包括吞噬体形成、延伸、自噬体和与溶酶体融合形成自噬体等一系列活动。mirna通过间接或直接途径对CRC相关的自噬通路发挥双重调控作用。图中，紫色方框代表间接调控自噬过程的自噬相关蛋白（如Bcl‐2、mTOR），绿色方框代表直接参与自噬发生或形成的自噬相关蛋白（如Beclin 1、LC3），黄色方框代表细胞过程。
Colorectal cancer (CRC) has become a concern because of its high recurrence rate and metastasis rate, low early diagnosis rate and poor therapeutic effect. At present, various studies have shown that autophagy is closely connected with the occurrence and progression of CRC. Autophagy is a highly cytosolic catabolic process involved in lysosomes in biological evolution. Cells degrade proteins and damaged organelles by autophagy to achieve material circulation and maintain cell homeostasis. Moreover, microRNAs are key regulators of autophagy, and their mediated regulation of transcriptional and post‐transcriptional levels plays an important role in autophagy in CRC cells. This review focuses on the recent research advances of how autophagy and related microRNAs are involved in affecting occurrence and progression of CRC and provides a new perspective for the study of CRC treatment strategies. Regulatory relationship between miRNAs and autophagy in CRC. Autophagy consists of a series of activities, such as phagophore formation, elongation, autophagosome and fusion with lysosome to form autolysosome. MiRNAs exert dual regulatory effects on autophagy pathways related to CRC through indirect or direct pathways. In the figure, the purple box represents autophagy‐related proteins, which indirectly regulate the autophagy process (eg, Bcl‐2, mTOR), the green box represents autophagy‐associated proteins, which are directly involved in the occurrence or formation of autophagy (eg, Beclin 1, LC3), and the yellow box represents the cellular process.
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影响因子：
4.6
作者：
Che, Jing;Wang, Wenshan;Yuan, Xianglin
通讯作者：
Yuan, Xianglin
DOI：
10.1158/1078-0432.ccr-09-1249
发表时间：
2009-12-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Gulhati P;Cai Q;Li J;Liu J;Rychahou PG;Qiu S;Lee EY;Silva SR;Bowen KA;Gao T;Evers BM
通讯作者：
Evers BM
癌代谢中的葡萄糖转运蛋白。
影响因子：
3.4
作者：
Adekola K;Rosen ST;Shanmugam M
通讯作者：
Shanmugam M
影响因子：
45.3
作者：
Bécouarn, Y;Ychou, M;Rougier, P
通讯作者：
Rougier, P
影响因子：
50.3
作者：
Calon A;Espinet E;Palomo-Ponce S;Tauriello DV;Iglesias M;Céspedes MV;Sevillano M;Nadal C;Jung P;Zhang XH;Byrom D;Riera A;Rossell D;Mangues R;Massagué J;Sancho E;Batlle E
通讯作者：
Batlle E