Noninvasive identification of patients with early coronary atherosclerosis by assessment of digital reactive hyperemia
Noninvasive identification of patients with early coronary atherosclerosis by assessment of digital reactive hyperemia
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DOI：
10.1016/j.jacc.2004.08.062
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发表时间：
2004-12-07
影响因子：
24
通讯作者：
Lerman, A
中科院分区：
文献类型：
--
作者：
Bonetti, PO;Pumper, GM;Lerman, A
我们研究了反应性充血外周动脉张力测定（RH-PAT）作为一种无创性工具来识别冠状动脉微血管内皮功能障碍个体的价值。RH-PAT是一种评价外周微血管内皮功能的技术。对94例无阻塞性冠状动脉疾病且冠状动脉微血管内皮功能正常（n = 39）或异常（n = 55）的患者在反应性充血期间的数字脉搏容积变化进行了评估; RH-PAT指数，反应性充血的测量，结果冠脉内皮功能不全患者的平均RH-PAT指数低于冠脉内皮功能正常者（1.27 +/- 0.05对比1.78 +/- 0.08：p < 0.001）。一个RH-PAT指数< 1.35被发现有80%的敏感性和85%的特异性，以确定患者与冠状动脉内皮dysfunction.CONCLUSIONS指充血反应，测量RH-PAT，在冠状动脉微血管内皮功能障碍的患者减弱，这表明RH-PAT作为一种非侵入性的测试，以确定这种疾病的患者的作用。(C)2004年，美国心脏病学会基金会。
OBJECTIVES We investigated the value of reactive hyperemia peripheral arterial tonometry (RH-PAT) as a noninvasive tool to identify individuals with coronary microvascular endothelial dysfunction.BACKGROUND Coronary endothelial dysfunction, a systemic disorder, represents an early stage of atherosclerosis; RH-PAT is a technique to assess peripheral microvascular endothelial function.METHODS Using RH-PAT, digital pulse volume changes during reactive hyperemia were assessed in 94 patients without obstructive coronary artery disease and either normal (n = 39) or abnormal (n = 55) coronary microvascular endothelial function; RH-PAT index, a measure of reactive hyperemia, was calculated as the ratio of the digital pulse volume during reactive hyperemia divided by that at baseline.RESULTS Average RH-PAT index was lower in patients with coronary endothelial dysfunction compared with those with normal coronary endothelial function (1.27 +/- 0.05 vs. 1.78 +/- 0.08: p < 0.001). An RH-PAT index < 1.35 was found to have a sensitivity of 80% and a specificity of 85% to identify patients with coronary endothelial dysfunction.CONCLUSIONS Digital hyperemic response, as measured by RH-PAT, is attenuated in patients with coronary microvascular endothelial dysfunction, suggesting a role for RH-PAT as a noninvasive test to identify patients with this disorder. (C) 2004 by the American College of Cardiology Foundation.