Lateral Entorhinal Cortex Lesions Impair Local Spatial Frameworks.
Lateral Entorhinal Cortex Lesions Impair Local Spatial Frameworks.
复制标题
DOI：
10.3389/fnsys.2017.00030
复制
发表时间：
2017
影响因子：
3
通讯作者：
Ainge JA
中科院分区：
文献类型：
--
作者：
Kuruvilla MV;Ainge JA
记忆加工神经生物学中的一个重要理论认为，情景记忆由海马体中的情境门控空间表征支持，该表征是由来自内侧内嗅皮层（MEC）的空间信息与来自外侧内嗅皮层（LEC）的非空间信息相结合而形成的。然而，来自啮齿动物损伤和单单元记录研究的越来越多的证据表明，LEC可能在编码空间中发挥作用，特别是在局部环境中物体的当前和以前的位置。地标，无论是本地的还是全球的，都被证明可以控制作为认知地图基础的空间表征。因此，最近有人提出，该网络中的信息处理可以参照空间尺度进行组织，LEC和MEC分别提供有关本地和全球空间框架的信息。在本研究中，我们训练动物使用局部或全局空间框架来寻找食物。在接受MEC或LEC的兴奋性毒性损伤后，对动物进行了两项任务的重新测试。LEC损伤的动物学习局部空间框架任务的能力受损。LEC损伤的动物在涉及多个局部特征的物体识别（OR）任务中也受到损害，但在识别单个熟悉物体时没有受到损害。总之，这表明LEC参与了局部环境特征的关联。然而，LEC和MEC病变都没有损害整体空间框架任务的表现。
A prominent theory in the neurobiology of memory processing is that episodic memory is supported by contextually gated spatial representations in the hippocampus formed by combining spatial information from medial entorhinal cortex (MEC) with non-spatial information from lateral entorhinal cortex (LEC). However, there is a growing body of evidence from lesion and single-unit recording studies in rodents suggesting that LEC might have a role in encoding space, particularly the current and previous locations of objects within the local environment. Landmarks, both local and global, have been shown to control the spatial representations hypothesized to underlie cognitive maps. Consequently, it has recently been suggested that information processing within this network might be organized with reference to spatial scale with LEC and MEC providing information about local and global spatial frameworks respectively. In the present study, we trained animals to search for food using either a local or global spatial framework. Animals were re-tested on both tasks after receiving excitotoxic lesions of either the MEC or LEC. LEC lesioned animals were impaired in their ability to learn a local spatial framework task. LEC lesioned animals were also impaired on an object recognition (OR) task involving multiple local features but unimpaired at recognizing a single familiar object. Together, this suggests that LEC is involved in associating features of the local environment. However, neither LEC nor MEC lesions impaired performance on the global spatial framework task.