Birth weight and adult hypertension: cross-sectional study in a Japanese workplace population.
Birth weight and adult hypertension: cross-sectional study in a Japanese workplace population.
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DOI：
10.1253/circj.70.262
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发表时间：
2006-03
期刊：
影响因子：
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通讯作者：
K. Tamakoshi;H. Yatsuya;K. Wada;K. Matsushita;R. Otsuka;P. Yang;K. Sugiura;Yo Hotta;H. Mitsuhashi;T. Kondo;H. Toyoshima
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文献类型：
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作者：
K. Tamakoshi;H. Yatsuya;K. Wada;K. Matsushita;R. Otsuka;P. Yang;K. Sugiura;Yo Hotta;H. Mitsuhashi;T. Kondo;H. Toyoshima
背景在一些西方人群中，低出生体重与成人高血压有关。这种关联需要在日本人中进行评估。方法和结果对3，107名年龄在35-66岁的受试者（2，303名男性和804名女性）进行了基于人群的横断面研究。参与者回答了一份关于他们出生体重、血压、病史、父母病史和生活方式因素的问卷。高血压定义为收缩压≥ 140 mmHg和/或舒张压≥ 90 mmHg和/或正在接受抗高血压药物治疗。经年龄、性别、体重指数、父母病史和生活方式校正后的多元Logistic回归分析显示，高血压的校正优势比为1.26（95%置信区间：0.88-1.80）、1.00（参考），0.89（0.73-1.08）和0.70出生体重类别为<2，500 g、2，500-<3，000 g、3，000-<3，500 g、3，500- g的受试者分别为（0.49-1.00）（趋势p值=0.009）。此外，这种负相关在正常体重的受试者中明显。结论：在日本工作人群中，低出生体重与成人高血压独立相关。我们的研究结果支持先前在西方人群中观察到的逆相关性，并表明宫内环境损伤可能导致影响血压调节的胎儿器官的代谢和结构的永久性变化。
BACKGROUND Low birth weight has been associated with adult hypertension in several Western populations. This association needs to be evaluated in Japanese people. METHODS AND RESULTS A population-based cross-sectional study of 3,107 subjects (2,303 males and 804 females) aged 35-66 years was conducted. The participants responded to a questionnaire about their birth weights, blood pressure, medical history, parental history, and lifestyle factors. Hypertension was defined as systolic blood pressure > or =140 mmHg and/or diastolic blood pressure > or =90 mmHg and/or under treatment by anti-hypertensives. Multiple logistic regression analysis adjusted for age, sex, body mass index, parental history, and lifestyle revealed the adjusted odds ratios for hypertension were 1.26 (95% confidence interval: 0.88-1.80), 1.00 (reference), 0.89 (0.73-1.08) and 0.70 (0.49-1.00) in subjects in birth weight categories of <2,500 g, 2,500-<3,000 g, 3,000-<3,500 g, 3,500- g, respectively (p-value for trend =0.009). Furthermore, this inverse association was clearly pronounced in normal-weight subjects. CONCLUSION Low birth weight was independently associated with adult hypertension in the Japanese workplace population. Our results support the inverse association observed previously in Western populations and suggest that intrauterine environmental insults might lead to permanent changes in the metabolism and structure of the fetal organs influencing the regulation of blood pressure.