Leucine-Rich Alpha-2 Glycoprotein in Monitoring Disease Activity and Intestinal Stenosis in Inflammatory Bowel Disease
Leucine-Rich Alpha-2 Glycoprotein in Monitoring Disease Activity and Intestinal Stenosis in Inflammatory Bowel Disease
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DOI：
10.1620/tjem.2022.j042
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发表时间：
2022-08-01
影响因子：
2.2
通讯作者：
Iijima, Katsunori
中科院分区：
文献类型：
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作者：
Yoshida, Tatsuki;Shimodaira, Yosuke;Iijima, Katsunori
富亮氨酸α -2糖蛋白（LRG）是一种监测炎症性肠病（IBD）疾病活动性的新型生物标志物。本研究的目的是评估其在监测疾病活动方面的效用。在这项基于我们两个中心2020年8月至2021年7月病例记录的回顾性研究中，我们检查了IBD患者血清LRG和c反应蛋白（CRP）水平与疾病活动性之间的相关性。分析了与血清LRG水平相关的背景因素。总共评估了47例克罗恩病（CD）和123例溃疡性结肠炎（UC）患者。在CD患者中，LRG和CRP水平与Harvey-Bradshaw指数（HBI）和简单内镜下CD评分（SES-CD）相关（LRG和HBI， r = 0.397； LRG和SES-CD， r = 0.637； CRP和HBI， r = 0.253； CRP和SES-CD， r = 0.332）。UC患者LRG、CRP与部分梅奥评分（PMS）、梅奥内镜亚评分（MES）显著相关（LRG、PMS r = 0.3; CRP、PMS r = 0.282; LRG、MES r = 0.424; CRP、MES r = 0.459）。在CRP正常的CD患者中，粘膜炎症组血清LRG水平明显高于粘膜愈合组（16.4 μ g/ mL vs. 10.7 μ g/ mL）。经多元回归分析，CD组狭窄程度与血清LRG水平相关。因此，LRG是监测疾病活动性和粘膜炎症的有用生物标志物，可以指示IBD患者肠道狭窄的状态。
Leucine-rich alpha-2 glycoprotein (LRG) is a novel biomarker for monitoring disease activity in inflammatory bowel disease (IBD). The aim of this study was to evaluate its utility in monitoring disease activity. In this retrospective study based on case records between August 2020 and July 2021 at our two centers, we examined the correlation between serum levels of LRG and C-reactive protein (CRP) with disease activity in IBD patients. Background factors related to serum LRG levels were also analyzed. Overall. 47 Crohn's disease (CD) and 123 ulcerative colitis (UC) patients were evaluated. In patients with CD, LRG and CRP levels correlated with Harvey-Bradshaw Index (HBI) and Simple Endoscopic Score for CD (SES-CD) (LRG and HBI, r = 0.397; LRG and SES-CD, r = 0.637; CRP and HBI, r = 0.253; CRP and SES-CD, r = 0.332). In patients with UC, LRG and CRP significantly correlated with the partial Mayo score (PMS) and Mayo endoscopic subscore (MES) (LRG and PMS, r = 0.3; CRP and PMS, r = 0.282; LRG and MES, r = 0.424; CRP and MES, r = 0.459). In CD patients with normal CRP, serum LRG level was significantly higher in those with mucosal inflammation than in those with mucosal healing (16.4 vs. 10.7 mu g/ mL). Stenosis was associated with serum LRG levels in CD group using multiple regression analysis. Therefore, LRG is a useful biomarker for monitoring disease activity and mucosal inflammation, and indicates the status of intestinal stenosis in IBD patients.