Functionally distinct amygdala subregions identified using DTI and high-resolution fMRI
Functionally distinct amygdala subregions identified using DTI and high-resolution fMRI
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DOI：
10.1093/scan/nsv055
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发表时间：
2015-12-01
影响因子：
4.2
通讯作者：
Helmstetter, Fred J.
中科院分区：
文献类型：
--
作者：
Balderston, Nicholas L.;Schultz, Douglas H.;Helmstetter, Fred J.
虽然杏仁核通常与恐惧和情绪直接相关，但杏仁核神经元会被各种情绪和非情绪刺激激活。杏仁核内的不同分区可能优先参与情绪和非情绪任务的不同方面。为了验证这一假设，我们测量并比较了新奇感和恐惧感对杏仁核活动的影响。我们使用高分辨率血氧水平依赖（BOLD）成像和流线型纤维束成像将杏仁核细分为三个不同的功能亚基。我们确定了一个laterobasal亚区连接的视觉皮层，一般响应视觉刺激，一个非投射区，响应显着的视觉刺激，和一个centromedial亚区连接的间脑，只有当视觉刺激预测一个令人厌恶的结果。我们提供解剖和功能的杏仁核功能的模型，其中信息进入通过laterobasal亚区，是由内在的电路在散布的组织处理，然后传递到centromedial亚区，激活导致行为输出的支持。
Although the amygdala is often directly linked with fear and emotion, amygdala neurons are activated by a wide variety of emotional and non-emotional stimuli. Different subregions within the amygdala may be engaged preferentially by different aspects of emotional and non-emotional tasks. To test this hypothesis, we measured and compared the effects of novelty and fear on amygdala activity. We used high-resolution blood oxygenation level-dependent (BOLD) imaging and streamline tractography to subdivide the amygdala into three distinct functional subunits. We identified a laterobasal subregion connected with the visual cortex that responds generally to visual stimuli, a non-projecting region that responds to salient visual stimuli, and a centromedial subregion connected with the diencephalon that responds only when a visual stimulus predicts an aversive outcome. We provide anatomical and functional support for a model of amygdala function where information enters through the laterobasal subregion, is processed by intrinsic circuits in the interspersed tissue, and is then passed to the centromedial subregion, where activation leads to behavioral output.