Sleep and circadian rhythm disturbance in bipolar disorder
Sleep and circadian rhythm disturbance in bipolar disorder
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DOI：
10.1017/s0033291717000186
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发表时间：
2017-07-01
影响因子：
6.9
通讯作者：
Anderson, K. N.
中科院分区：
文献类型：
--
作者：
Bradley, A. J.;Webb-Mitchell, R.;Anderson, K. N.
背景。失眠和嗜睡的主观报告在双相情感障碍 (BD) 中很常见。目前尚不清楚这些与潜在的昼夜节律紊乱（CRD）有多大关系。在这项研究中，我们的目的是与匹配的对照组相比，客观评估 BD 患者队列的睡眠和昼夜节律。 46 名 BD 患者和 42 名对照者接受了全面的睡眠/昼夜节律评估，包括呼吸睡眠研究、3 周以上的延长加速测量、睡眠问卷和日记、褪黑激素水平以及情绪、心理社会功能和生活质量 (QoL) 问卷。结果。 23 名 (50%) BD 患者存在睡眠异常，其中 12 名 (52%) 患有 CRD，29% 患有阻塞性睡眠呼吸暂停。与对照组和睡眠正常的患者相比，睡眠异常的患者 24 小时褪黑激素分泌量较低。 BD 中的异常睡眠/CRD 与功能受损和较差的生活质量相关。结论。 BD 与睡眠异常和 CRD 的高发生率有关。这些疾病、情绪和功能之间的关联以及因果关系的方向值得进一步研究。
Background. Subjective reports of insomnia and hypersomnia are common in bipolar disorder (BD). It is unclear to what extent these relate to underlying circadian rhythm disturbance (CRD). In this study we aimed to objectively assess sleep and circadian rhythm in a cohort of patients with BD compared to matched controls.Method. Forty-six patients with BD and 42 controls had comprehensive sleep/circadian rhythm assessment with respiratory sleep studies, prolonged accelerometry over 3 weeks, sleep questionnaires and diaries, melatonin levels, alongside mood, psychosocial functioning and quality of life (QoL) questionnaires.Results. Twenty-three (50%) patients with BD had abnormal sleep, of whom 12 (52%) had CRD and 29% had obstructive sleep apnoea. Patients with abnormal sleep had lower 24-h melatonin secretion compared to controls and patients with normal sleep. Abnormal sleep/CRD in BD was associated with impaired functioning and worse QoL.Conclusions. BD is associated with high rates of abnormal sleep and CRD. The association between these disorders, mood and functioning, and the direction of causality, warrants further investigation.