A comparative trial of a single-dose ivermectin versus three days of albendazole for treatment of Strongyloides stercoralis and other soil-transmitted helminth infections in children
A comparative trial of a single-dose ivermectin versus three days of albendazole for treatment of Strongyloides stercoralis and other soil-transmitted helminth infections in children
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DOI：
10.4269/ajtmh.1996.55.477
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发表时间：
1996-11-01
影响因子：
3.3
通讯作者：
Hatz, C
中科院分区：
文献类型：
--
作者：
Marti, H;Haji, HJ;Hatz, C
描述了在桑给巴尔农村进行的一项随机试验，比较了单剂量200 μ g/kg伊维菌素和400 mg/天连续3天的阿苯达唑治疗类圆线虫病和其他肠道线虫病。在301例粪类圆线虫感染的儿童中，伊维菌素或阿苯达唑治疗的治愈率分别为83%和45%。虽然这两种药物对蛔虫都非常有效，但鞭虫仅在11%（伊维菌素）和43%（阿苯达唑）的受试者中治愈，尽管平均产卵量分别减少了59%和92%。伊维菌素对钩虫无效，而阿苯达唑的治愈率为98%。两种治疗均未记录严重副作用，轻度副作用均为一过性。因此，伊维菌素提供了一种安全和高效的单剂量治疗S。stercoralis和A.但不能作为治疗T.鞭虫和钩虫感染。
A randomized trial carried out in rural Zanzibar comparing a single dose of 200 mu g/kg of ivermectin and 400 mg/day for three days of albendazole for treatment of strongyloidiasis and other intestinal nematodes is described. In 301 children with Strongyloides stercoralis infection, treatment with ivermectin or albendazole resulted in cure rates of 83% and 45%, respectively. While both drugs were very effective against Ascaris lumbricoides, Trichuris trichiura was cured only in 11% (ivermectin) and 43% (albendazole) of the subjects, although the mean eggload was reduced by 59% and 92%, respectively. Ivermectin was ineffective against hookworms, while albendazole resulted in a cure rate of 98%. No severe side effects were recorded and mild side effects were of transient nature for both treatments. Therefore, ivermectin provides a safe and highly effective single dose treatment for S. stercoralis and A. lumbricoides, while it is not an alternative for the treatment of T. trichiura and hookworm infections.