QUANTITATIVE AND QUALITATIVE CHANGES IN HISTONE GENE-EXPRESSION DURING EARLY MOUSE EMBRYO DEVELOPMENT
QUANTITATIVE AND QUALITATIVE CHANGES IN HISTONE GENE-EXPRESSION DURING EARLY MOUSE EMBRYO DEVELOPMENT
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DOI：
10.1073/pnas.82.17.5685
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发表时间：
1985-01-01
影响因子：
11.1
通讯作者：
SCHULTZ, GA
中科院分区：
文献类型：
--
作者：
GRAVES, RA;MARZLUFF, WF;SCHULTZ, GA
在小鼠卵子中存在大量的组蛋白mRNA。这些RNA迅速降解，受精后第二次卵裂前的其他mRNAs也是如此。在卵裂过程中，组蛋白mRNA随着胚胎的分裂而积累。相同的组蛋白基因在卵子和胚胎中表达，尽管特定的组蛋白mRNAs的数量有很大的质的差异。卵子组蛋白mRNA的功能尚不清楚。卵裂期和囊胚期的组蛋白信使核糖核酸可能足以编码囊胚期的组蛋白。
There are large amounts of histone mRNA present in mouse eggs. These RNAs are rapidly degraded, as are other mRNAs after fertilization and prior to the second cleavage. During cleavage, the histone mRNA accumulates as the embryo divides. The same sets of histone genes are expressed in eggs and embryos, although there are large qualitative differences in the amounts of particular histone mRNAs. The function of the egg histone mRNA is unknown. The amount of histone mRNA in cleaving and blastocyst embryos is probably sufficient to code for the blastocyte histone proteins.