UCP2 and PLIN1 Expression Affects the Resting Metabolic Rate and Weight Loss on Obese Patients
UCP2 and PLIN1 Expression Affects the Resting Metabolic Rate and Weight Loss on Obese Patients
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DOI：
10.1007/s11695-016-2275-0
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发表时间：
2017-02-01
期刊：
影响因子：
2.9
通讯作者：
Nonino, Carla Barbosa
中科院分区：
文献类型：
--
作者：
Parenti de Oliveira, Bruno Affonso;de Souza Pinhel, Marcela Augusta;Nonino, Carla Barbosa
分析与能量代谢相关的基因表达可以阐明导致肥胖的生理和遗传因素。本研究旨在评估肥胖患者减肥手术前后基因的表达及其对静息代谢率和体重减轻的影响。这项研究对23名女性进行，分为两组：减肥手术组（术前和术后6个月）和对照组。收集腹部皮下脂肪组织样本进行基因表达分析，并通过间接量热法测量静息代谢率（RMR）。减肥手术后体重减轻（22％，p = 0.01）、BMI（22.5％，p = 0.01）和RMR值（10.5％，p = 0.01）观察到显着差异，而 体重调整后的 RMR 增加（15.8%，p = 0.01）。与术前相比，Roux-en-Y 胃绕道手术 (RYGB) 6 个月后观察到 UCP2 表达增加（0.764 至 1.268，p = 0.01）。以体重调整后的 RMR 作为因变量进行分析表明，UCP2 (r (2) = 0.517，p = 0.01) 和 PLIN1 (r (2) = 0.420，p = 0.04) 的表达决定了术前的 RMR 值。此外，术前UCP2和PLIN1表达影响体重减轻的百分比，即使根据年龄和BMI进行调整。我们已经证明，减肥手术6个月后，UCP2表达显着增加。此外，UCP2 和 PLIN1 基因的表达会影响肥胖个体的静息代谢率，并可以预测减肥手术后的体重减轻。
Analysis of the expression of genes related to the energy metabolism can elucidate the understanding of physiological and genetic factors that contribute to obesity. This study aimed to evaluate the expression of genes and its influence on resting metabolic rate and weight loss in obese patients before and after bariatric surgery.This study was conducted on 23 women, who were divided into two groups: bariatric surgery (preoperative and 6 months after surgery) and control. Abdominal subcutaneous adipose tissue samples were collected to analyze the gene expression, and the resting metabolic rate (RMR) was measured by indirect calorimetry.Significant differences were observed in weight reduction (22 %, p = 0.01), BMI (22.5 %, p = 0.01), and RMR values (10.5 %, p = 0.01) after the bariatric surgery, while the weight-adjusted RMR increased (15.8 %, p = 0.01). Increased UCP2 expression after 6 months of Roux-en-Y gastric bypass (RYGB) as compared to preoperative period (0.764 to 1.268, p = 0.01) was observed. Analysis with weight-adjusted RMR as dependent variable revealed that UCP2 (r (2) = 0.517, p = 0.01) and PLIN1 (r (2) = 0.420, p = 0.04) expression determine the RMR values in preoperative period. Moreover, UCP2 and PLIN1 expression in preoperative period influenced the percentage of weight loss, even when adjusted for age and BMI.We have demonstrated that after 6 months of bariatric surgery, there is significant increase in the UCP2 expression. Additionally, the expression of UCP2 and PLIN1 genes influences the resting metabolic rate in obese individuals and could predict the weight loss after bariatric surgery.