Higher Ki67 expression in fibroblast like cells at invasive front indicates better clinical outcomes in oral squamous cell carcinoma patients
Higher Ki67 expression in fibroblast like cells at invasive front indicates better clinical outcomes in oral squamous cell carcinoma patients
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侵袭前沿成纤维细胞样细胞中较高的 Ki67 表达表明口腔鳞状细胞癌患者具有更好的临床结果
DOI：
10.1042/bsr20181271
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发表时间：
2018-12-21
影响因子：
4
通讯作者：
Ni, Yanhong
中科院分区：
文献类型：
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作者：
Jing, Yue;Yang, Yan;Ni, Yanhong
背景资料：Ki 67在某些肿瘤的治疗选择和预后评估中起着关键作用，但Ki 67在口腔鳞状细胞癌（OSCC）中的空间表达尚未得到充分评价。因此，在本研究中，我们的目的是阐明Ki 67空间表达的预后价值，包括在不同的细胞类型和在肿瘤的不同分区在口腔鳞癌患者。研究方法：采用免疫组化法检测109例口腔鳞癌患者癌组织中肿瘤细胞（TC）、癌中心（CT）和浸润前沿（IF）成纤维细胞样细胞（FLC）中Ki 67的表达。采用卡方检验分析Ki 67表达与临床病理参数的相关性，Kaplan-Meier法分析生存曲线。采用考克斯回归模型对Ki 67表达的诊断价值进行单因素和多因素分析。结果如下：在CT和IF区，TC的Ki 67表达均明显高于FLC，但CT区TC的Ki 67表达高于IF区（P=0.0004），而FLC的Ki 67表达则匡威（P
Background: Ki67 has been a key role for the treatment options and prognosis evaluation in some kinds of tumors; however, the spatial expression of Ki67 in oral squamous cell carcinoma (OSCC) has not been fully-evaluated. Therefore, in the present study, we aimed to elucidate the prognosis value of Ki67 spatial expression including in different cell types and at different compartments of tumor in OSCC patients. Methods: Immunohistochemical expression of Ki67 in tumor cells (TCs) and fibroblast like cells (FLCs) at center of tumor (CT) and invasive front (IF) was evaluated in 109 OSCC patients. Then correlations of Ki67 expressions with clinicopathological parameters were analyzed by Chi-square test, and survival curves were evaluated by Kaplan-Meier methods. Furthermore, univariate and multivariate analysis were performed to assess the diagnostic values of Ki67 expression by the Cox regression model. Results: Ki67 expression in TCs was much higher than in FLCs both at CT and IF compartments, but Ki67 expression in TCs was simultaneously higher at CT than that at IF (P=0.0004), which was converse to Ki67 expression in FLCs (P