DEVELOPMENT OF PRIMORDIAL AND DEFINITIVE AMNIOTIC CAVITIES IN EARLY RHESUS-MONKEY AND HUMAN EMBRYOS
DEVELOPMENT OF PRIMORDIAL AND DEFINITIVE AMNIOTIC CAVITIES IN EARLY RHESUS-MONKEY AND HUMAN EMBRYOS
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DOI：
10.1002/aja.1001440204
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发表时间：
1975-01-01
影响因子：
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通讯作者：
LUCKETT, WP
中科院分区：
文献类型：
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作者：
LUCKETT, WP
对华盛顿卡耐基研究所收集的早期恒河猴和人类胚胎的重新检查表明，两者的羊膜发生机制基本类似于刺猬和蝙蝠。在出生10天的恒河猴和出生7天的人类胚泡胚团中，通过空化形成原始羊膜腔。与先前的报道相反，这个原始腔最初与上面的滋养层没有关系。随后，原始腔的外胚芽顶变薄并向外扩张，导致顶部部分打开，形成微杯状的胚胎盘。所得空间与原始羊膜腔不同源；相反，它是一个过渡性营养外胚层腔。最终羊膜上皮由外胚盘边缘的上折叠和有丝分裂增殖形成；这个过程在11天和9天的恒河猴囊胚中完成。通过空化的羊膜形成与着床后极性滋养细胞的持续存在有关，这一空化过程可能是为原始条纹形成过程中外胚层细胞的形态发生运动提供自由上皮表面所必需的。
Re‐examination of early rhesus monkey and human embryos in the collection of the Carnegie Institution of Washington suggests that the mechanism of amniogenesis in both is basically similar to that of the hedgehog and vespertilionid bats. A primordial amniotic cavity develops by cavitation within the embryonic mass of 10‐day rhesus monkey, and 7‐day human, blastocysts. This primordial cavity has no relationship initially with the overlying trophoblast, contrary to earlier reports. Subsequently, there is a thinning and peripheral spreading of the epiblastic roof of the primordial cavity, resulting in partial opening of the roof and formation of a slightly cupped embryonic disc. The resulting space is not homologous with the primordial amniotic cavity; instead, it is a transitorytropho‐epiblastic cavity. The definitive amniotic epithelium forms by the upfolding and mitotic proliferation of the margins of the epiblastic disc; this process is completed in 11‐day rhesus, and 9‐day human, blastocysts.Amniogenesis by cavitation is associated with the persistence of polar trophoblast following implantation, and it is suggested that this cavitation process may be essential for providing a free epithelial surface for the morphogenetic movement of epiblastic cells during subsequent formation of the primitive streak.