High expression of Nectin-4 is associated with unfavorable prognosis in gastric cancer
High expression of Nectin-4 is associated with unfavorable prognosis in gastric cancer
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Nectin-4的高表达与胃癌不良预后相关
DOI：
10.3892/ol.2018.8365
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发表时间：
2018-06-01
期刊：
影响因子：
2.9
通讯作者：
Ni, Qingfeng
中科院分区：
文献类型：
--
作者：
Zhang, Yan;Zhang, Jiaxuan;Ni, Qingfeng
Nectin是钙离子非依赖性免疫球蛋白样细胞粘附分子，属于一个四个成员的家族，在许多生物细胞活动中发挥作用。Nectin-4在几种类型的人类癌症中过表达;然而，Nectin-4在胃癌（GC）中的功能和预后意义仍不清楚。本研究应用逆转录-定量聚合酶链反应（RT-PCR）和组织芯片免疫组化技术，探讨Nectin-4在胃癌组织中的表达及其在胃癌预后中的作用。结果表明，肿瘤组织中Nectin-4的mRNA和蛋白表达均高于相应的非肿瘤组织。Nectin-4的表达与分化程度（P=0.004）、原发灶（P=0.001）、淋巴结转移（P
Nectins are Ca2+-independent immunoglobulin-like cell adhesion molecules that belong to a family of four members that function in a number of biological cellular activities. Nectin-4 is overexpressed in several types of human cancer; however, the functional and prognostic significance of Nectin-4 in gastric cancer (GC) remains unclear. In the present study, the reverse transcription-quantitative polymerase chain reaction and tissue microarray immunohistochemical analysis were used to investigate the expression of Nectin-4 in GC as well as its function in the prognosis of patients with GC. The results indicated that mRNA and protein expression of Nectin-4 were increased in tumor tissues compared with the matched non-tumor tissues. Expression of Nectin-4 was closely associated with differentiation (P=0.004), primary tumor (P=0.001), lymph node metastasis (P