Multiple factors influence calcium synchronization in arterial vasomotion.
Multiple factors influence calcium synchronization in arterial vasomotion.
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DOI：
10.1016/j.bpj.2011.12.032
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发表时间：
2012-01
影响因子：
3.4
通讯作者：
A. Kapela;Jaimit Parikh;N. Tsoukias
中科院分区：
文献类型：
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作者：
A. Kapela;Jaimit Parikh;N. Tsoukias
在单个平滑肌细胞中，自发钙（Ca 2+）振荡的细胞间同步是血管舒缩的先决条件。一个详细的数学模型，在大鼠肠系膜动脉中的Ca 2+动力学表明，一些同步化和去钙化途径可能参与。特别是，Ca2+依赖性磷脂酶C，三磷酸肌醇（IP3，并在较小程度上Ca2+），IP3受体，二酰基甘油激活的非选择性阳离子通道，和Ca2+激活的氯离子通道的细胞间扩散可以有助于同步，而大电导Ca2+激活的钾离子通道具有去磷酸化作用。取决于收缩状态和激动剂浓度，不同的途径成为主导，并可以通过仔细抑制其总活性的振荡分量来揭示。Ca2+和膜电位振荡之间的相移可以改变，因此通过间隙连接的电耦合可以介导同步或去同步化。内皮的作用是高度可变的，因为它可以同时增强细胞间的耦合，并影响多种平滑肌细胞成分。在这里，我们概述了一个系统的复杂性增加，并提出了潜在的同步机制，需要进行实验测试。
The intercellular synchronization of spontaneous calcium (Ca2+) oscillations in individual smooth muscle cells is a prerequisite for vasomotion. A detailed mathematical model of Ca2+dynamics in rat mesenteric arteries shows that a number of synchronizing and desynchronizing pathways may be involved. In particular, Ca2+-dependent phospholipase C, the intercellular diffusion of inositol trisphosphate (IP3, and to a lesser extent Ca2+), IP3receptors, diacylglycerol-activated nonselective cation channels, and Ca2+-activated chloride channels can contribute to synchronization, whereas large-conductance Ca2+-activated potassium channels have a desynchronizing effect. Depending on the contractile state and agonist concentrations, different pathways become predominant, and can be revealed by carefully inhibiting the oscillatory component of their total activity. The phase shift between the Ca2+and membrane potential oscillations can change, and thus electrical coupling through gap junctions can mediate either synchronization or desynchronization. The effect of the endothelium is highly variable because it can simultaneously enhance the intercellular coupling and affect multiple smooth muscle cell components. Here, we outline a system of increased complexity and propose potential synchronization mechanisms that need to be experimentally tested.