Gene Set Knowledge Discovery with Enrichr.
Gene Set Knowledge Discovery with Enrichr.
复制标题
使用Enrichr进行基因集知识发现。
DOI：
10.1002/cpz1.90
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发表时间：
2021-03
期刊：
影响因子：
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通讯作者：
Ma'ayan A
中科院分区：
文献类型：
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作者：
Xie Z;Bailey A;Kuleshov MV;Clarke DJB;Evangelista JE;Jenkins SL;Lachmann A;Wojciechowicz ML;Kropiwnicki E;Jagodnik KM;Jeon M;Ma'ayan A
利用基因组学、转录组学、表观基因组学、蛋白质组学和代谢组学分析来自患者、组织和细胞的样本，最终产生需要在已知生物学背景下进一步分析和整合的基因和蛋白质列表。Enrichr是一个基因集搜索引擎，可以查询数十万个注释的基因集。Enrichr独特地整合了来自许多备受瞩目的项目的知识，以提供有关哺乳动物基因和基因组的综合信息。该平台可在https：//maayanlab.cloud/Enrichr上获得，提供了计算基因集富集的各种方法，并以多种交互方式可视化结果。该协议提供了Enrichr的主要功能的摘要，其中包括以编程方式使用Enrichr和在任何网站上嵌入Enrichr按钮。
Profiling samples from patients, tissues, and cells with genomics, transcriptomics, epigenomics, proteomics, and metabolomics ultimately produce lists of genes and proteins that need to be further analyzed and integrated in the context of known biology. Enrichr is a gene set search engine that enables the querying of hundreds of thousands of annotated gene sets. Enrichr uniquely integrates knowledge from many high-profile projects to provide synthesized information about mammalian genes and gene sets. The platform, available at https://maayanlab.cloud/Enrichr, provides various methods to compute gene set enrichment and the results are visualized in several interactive ways. This protocol provides a summary of the key features of Enrichr, which include using Enrichr programmatically and embedding an Enrichr button on any website.