MiR-147: Functions and Implications in Inflammation and Diseases.
MiR-147: Functions and Implications in Inflammation and Diseases.
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DOI：
10.2174/2211536610666210707113605
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发表时间：
2021
影响因子：
--
通讯作者：
Hu K
中科院分区：
文献类型：
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作者：
Lin L;Hu K
microRNAs（miRNAs）是一类长度为19~25个核苷酸的小分子非编码RNA，通过抑制mRNA的翻译或降解，在转录后水平调控基因的表达。最初在小鼠脾脏和巨噬细胞中发现的miR-147已被证明与冠状动脉粥样硬化形成和炎症性肠病相关，并通过TLR-4调节巨噬细胞功能和炎症。miR-147在多种人类疾病中的表达发生了改变，包括感染性疾病、癌症、心血管疾病、神经退行性疾病等。本文就miR-147在炎症和疾病中的作用进行综述。
MicroRNAs (miRNAs) are small non-coding RNAs (19~25 nucleotides) that regulate gene expression at a post-transcriptional level through repression of mRNA translation or mRNA decay. miR-147, which was initially discovered in mouse spleen and macrophages, has been shown to correlate with coronary atherogenesis and inflammatory bowel disease, and modulate macrophage functions and inflammation through TLR-4. Altered miR-147 level has been shown in various human diseases including infectious disease, cancer, cardiovascular disease, neurodegenerative disorder, etc. This review will focus on the current understanding regarding the role of miR-147 in inflammation and diseases.