Activating transcription factor 1 promoted migration and invasion in lung cancer cells through regulating EGFR and MMP-2
Activating transcription factor 1 promoted migration and invasion in lung cancer cells through regulating EGFR and MMP-2
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DOI：
10.1002/mc.23086
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发表时间：
2019-08-16
影响因子：
4.6
通讯作者：
Li, Dang
中科院分区：
文献类型：
--
作者：
Cui, Jinggang;Yin, Zhaofang;Li, Dang
肺癌是世界范围内最常见的癌症之一，也是癌症相关死亡的主要原因。非小细胞肺癌占所有肺癌病例的85%至90%，并发生远处转移，死亡率高。在这项工作中，我们阐明了激活转录因子1（ATF 1）在肺癌细胞迁移和侵袭中的作用。我们发现ATF 1基因沉默抑制了肺癌细胞的迁移和侵袭。相反，ATF 1过表达导致迁移和侵袭的促进。ATF 1表达的改变以相同的趋势诱导表皮生长因子受体（EGFR）和基质金属蛋白酶（MMP）-2表达水平的变化。因此，我们提供了一个潜在的新的候选治疗肺癌，显示潜在的机制，肺癌细胞的侵袭和迁移。
Lung cancer is among the most frequently occurring cancers and the leading cause of cancer-related deaths worldwide. Nonsmall cell lung cancer is accountable for 85% to 90% of all lung cancer cases and develops distant metastases with high mortality. In this work, we elucidated the role of activating transcription factor 1 (ATF1) in migration and invasion of lung cancer cells. We found that the migration and invasion were inhibited with ATF1 silencing in lung cancer cells. By contrast, ATF1 overexpression led to promotion in migration and invasion. The alteration in ATF1 expression induced a change in the epidermal growth factor receptor (EGFR) and matrix metalloproteinases (MMP)-2 expression level in the same tendency. Thus, we provided a potential new candidate for therapies against lung cancer, showing the possible mechanism underlying the invasion and migration of lung cancer cells.