TEMPERATURE DISTRIBUTIONS IN TUMOR-MODELS HEATED BY SELF-REGULATING NICKEL COPPER ALLOY THERMOSEEDS
TEMPERATURE DISTRIBUTIONS IN TUMOR-MODELS HEATED BY SELF-REGULATING NICKEL COPPER ALLOY THERMOSEEDS
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DOI：
10.1118/1.595490
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发表时间：
1984-01-01
期刊：
影响因子：
3.8
通讯作者：
CHAKRABORTY, DP
中科院分区：
文献类型：
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作者：
BREZOVICH, IA;ATKINSON, WJ;CHAKRABORTY, DP
针形热籽晶由70.4%Ni和29.6%Cu的合金制成。在不同温度下测量合金的磁性能;由此，计算由暴露于电磁感应场的热籽产生的加热功率作为籽晶温度的函数。还进行了量热测量。根据这些数据，计算了假设由Ni-Cu植入物阵列加热的简单肿瘤模型中的温度分布。Ni-Cu植入物比现有的恒定功率种子产生更好的温度均匀性，特别是在血液灌注率不可预测的肿瘤中或植入物排列不规则时。由于这种情况可能存在于实际患者中，因此Ni-Cu植入物在临床热疗[用于癌症治疗]中应该非常有用。
Needle-shaped thermoseeds were manufactured from an alloy consisting of 70.4% Ni and 29.6% Cu. The magnetic properties of the alloy were measured at various temperatures; from this, the heating power produce by a thermoseed exposed to an electromagnetic induction field was computed as a function of the seed temperature. Calorimetric measurements were also performed. From these data, temperature distributions in simple tumor models assumed to be heated by an array of Ni-Cu implants were computed. The Ni-Cu implants produce substantially better temperature homogeneity than readily available constant power seeds, especially in tumors with unpredictable rates of blood perfusion or when the implant arrangement is not prefectly regular. Since such conditions are likely to be present in actual patients, the Ni-Cu implants should be very useful in clinical hyperthermia [for cancer therapy].