Sulfur metabolism in Escherichia coli and related bacteria: facts and fiction.
Sulfur metabolism in Escherichia coli and related bacteria: facts and fiction.
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DOI：
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发表时间：
2000-04
影响因子：
1.2
通讯作者：
A. Sękowska;Hsiang-Fu Kung;Antoine Danchin
中科院分区：
文献类型：
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作者：
A. Sękowska;Hsiang-Fu Kung;Antoine Danchin
生物体是由氢、碳、氮、氧、磷和硫组成的大分子。关于前五种元素的代谢已经做了大量的工作，但关于硫的代谢还有很多需要了解的地方。本文综述了在大肠杆菌及相关细菌中的情况，目前已在该生物中发现了100多个参与硫代谢的基因。对基因组的检查表明，将会发现更多的基因，特别是参与调节、清除含硫分子和辅酶或辅酶基团合成的基因。此外，蛋氨酸作为蛋白质的普遍起点及其衍生物S-腺苷蛋氨酸参与了广泛的细胞过程，这证明硫代谢在所有生物体中都具有重要的意义。
Living organisms are composed of macromolecules made of hydrogen, carbon, nitrogen, oxygen, phosphorus and sulfur. Much work has been devoted to the metabolism of the first five elements, but much remains to be understood about sulfur metabolism. We review here the situation in Escherichia coli and related bacteria, where more than one hundred genes involved in sulfur metabolism have already been discovered in this organism. Examination of the genome suggests that many more will be found, especially genes involved in regulation, scavenging of sulfur containing molecules and synthesis of coenzymes or prosthetic groups. Furthermore, the involvement of methionine as the universal start of proteins as well as that of its derivative S-adenosylmethionine in a vast variety of cell processes argue in favour of a major importance of sulfur metabolism in all organisms.