3D printed tablets loaded with polymeric nanocapsules: An innovative approach to produce customized drug delivery systems
3D printed tablets loaded with polymeric nanocapsules: An innovative approach to produce customized drug delivery systems
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DOI：
10.1016/j.ijpharm.2017.05.074
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发表时间：
2017-08-07
影响因子：
5.8
通讯作者：
Gaisford, S.
中科院分区：
文献类型：
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作者：
Beck, R. C. R.;Chaves, P. S.;Gaisford, S.
多功能药物递送系统，即装载有纳米尺寸载体的固体剂型的产生，仍然很少探索，并且仍然是配方设计者的挑战。这是第一次，两个重要的技术，3D打印和纳米技术的耦合，以生产创新的固体剂型含有载药纳米胶囊在这里进行了评估。通过熔融沉积成型（FDM）由聚（ε-己内酯）（PCL）和Eudragit（R）RL 100（ERL）长丝在有或没有通道剂（甘露醇）的情况下制备药物递送装置。将它们浸泡在装载有deflazacort的纳米胶囊（粒径：138 nm）中，以产生装载有它们的3D打印片剂（printlet），如通过SEM观察到的。通过通道剂的存在提高了载药量，并且在浸泡时间和载药量之间获得了线性相关性（r（2）= 0.9739）。此外，药物释放曲线依赖于片剂的聚合物材料和通道剂的存在。特别地，用部分中空的芯（50%填充物）制备的片剂具有更高的载药量（0.27%w/w）和更快的药物释放速率。这项研究代表了一种将纳米胶囊悬浮液转化为固体剂型的原始方法，以及一种有效的3D打印方法来生产新型药物递送系统，如个性化纳米药物。(C)2017爱思唯尔B. V.保留所有权利。
The generation of multi-functional drug delivery systems, namely solid dosage forms loaded with nano-sized carriers, remains little explored and is still a challenge for formulators. For the first time, the coupling of two important technologies, 3D printing and nanotechnology, to produce innovative solid dosage forms containing drug-loaded nanocapsules was evaluated here. Drug delivery devices were prepared by fused deposition modelling (FDM) from poly(epsilon-caprolactone) (PCL) and Eudragit (R) RL100 (ERL) filaments with or without a channelling agent (mannitol). They were soaked in deflazacort-loaded nanocapsules (particle size: 138 nm) to produce 3D printed tablets (printlets) loaded with them, as observed by SEM. Drug loading was improved by the presence of the channelling agent and a linear correlation was obtained between the soaking time and the drug loading (r(2) = 0.9739). Moreover, drug release profiles were dependent on the polymeric material of tablets and the presence of the channelling agent. In particular, tablets prepared with a partially hollow core (50% infill) had a higher drug loading (0.27% w/w) and faster drug release rate. This study represents an original approach to convert nanocapsules suspensions into solid dosage forms as well as an efficient 3D printing method to produce novel drug delivery systems, as personalised nanomedicines. (C) 2017 Elsevier B.V. All rights reserved.