Spatial pattern of cerebral glucose metabolism (PET) correlates with localization of intracerebral EEG-generators in Alzheimer's disease
Spatial pattern of cerebral glucose metabolism (PET) correlates with localization of intracerebral EEG-generators in Alzheimer's disease
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DOI：
10.1016/s1388-2457(00)00427-2
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发表时间：
2000-10-01
影响因子：
4.7
通讯作者：
Nordberg, A
中科院分区：
文献类型：
--
作者：
Dierks, T;Jelic, V;Nordberg, A
背景：由于正电子发射断层扫描（PET）测量人脑葡萄糖代谢（GluM）和脑电图（EEG）测量人脑电活动反映突触活动，两者在大脑空间分布上应具有相关性。健康受试者确实表现出类似的代谢和神经电空间模式。目的：该研究的目的是表明这种GluM和EEG空间模式的相似性在糖代谢高度变异性的人群中是正确的。方法：采用[18F]FDG PET和EEG对健康对照者和不同程度认知功能障碍及不同GluM模式的患者进行调查。结果：脑电发生器的定位与GluM的空间指数相关。结论：EEG与GluM-PET提供了相似的脑功能空间信息。由于脑电图是一种非侵入性技术，比PET更广泛可用，可以更频繁地重复，这可能对神经精神病学研究和临床诊断都有重要意义。然而，等效EEG偶极子发生器是否能产生与GluM-PET相似的诊断特异性和敏感性，还需要进一步的研究来确定。(C) 2000爱思唯尔科学爱尔兰有限公司版权所有。
Background: Since the measurement of human cerebral glucose metabolism (GluM) by positron emission tomography (PET) and that of human cerebral electrical activity by EEG reflect synaptic activity, both methods should be related in their cerebral spatial distribution. Healthy subjects do indeed demonstrate similar metabolic and neuroelectric spatial patterns.Objective: The aim of the study was to show that this similarity of GluM and EEG spatial patterns holds true in a population with a high variability of glucose metabolism.Methods: We investigated healthy control subjects and patients with varying degrees of cognitive dysfunction and varying GluM patterns by applying [18F]FDG PET and EEG.Results: We demonstrated that the localization of intracerebral generators of EEG correlates with spatial indices of GluM.Conclusion: These results indicate that EEG provides similar spatial information about brain function as GluM-PET. Since EEG is a noninvasive technique, which is more widely available and can be repeated more often than PET, this may have important implications both for neuropsychiatric research and for clinical diagnosis. However, further studies are required to determine whether equivalent EEG dipole generators can yield a diagnostic specificity and sensitivity similar to that of GluM-PET. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.