The role of interleukin-22 in lung health and its therapeutic potential for COVID-19.
The role of interleukin-22 in lung health and its therapeutic potential for COVID-19.
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DOI：
10.3389/fimmu.2022.951107
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发表时间：
2022
影响因子：
7.3
通讯作者：
Chen, Wei
中科院分区：
文献类型：
--
作者：
Fang, Si;Ju, Dianwen;Lin, Yong;Chen, Wei
尽管已经实施了无数临床试验，但针对冠状病毒病的绝对有效治疗方法2019年(新冠肺炎)仍难以实现。近年来，白介素22(IL-22)引起了人们的极大兴趣，成为白介素10(IL-10)家族中研究最多的细胞因子之一。与大多数白介素类不同，由于受体表达受限，IL-22主要作用于成纤维细胞和上皮细胞。大量研究表明，IL-22通过显著改善免疫细胞介导的炎症反应，减轻组织损伤，进一步促进上皮修复和再生，在抗病毒感染中发挥重要作用。在此，我们特别关注IL-22在肺中的作用。我们总结了IL-22与肺部健康和疾病的关系的最新进展，并进一步讨论了调控这一细胞因子作为有效管理新冠肺炎的潜在免疫治疗策略。
Although numerous clinical trials have been implemented, an absolutely effective treatment against coronavirus disease 2019 (COVID-19) is still elusive. Interleukin-22 (IL-22) has attracted great interest over recent years, making it one of the best-studied cytokines of the interleukin-10 (IL-10) family. Unlike most interleukins, the major impact of IL-22 is exclusively on fibroblasts and epithelial cells due to the restricted expression of receptor. Numerous studies have suggested that IL-22 plays a crucial role in anti-viral infections through significantly ameliorating the immune cell-mediated inflammatory responses, and reducing tissue injury as well as further promoting epithelial repair and regeneration. Herein, we pay special attention to the role of IL-22 in the lungs. We summarize the latest progress in our understanding of IL-22 in lung health and disease and further discuss maneuvering this cytokine as potential immunotherapeutic strategy for the effective manage of COVID-19.
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影响因子：
120.7
作者：
Caricchio, Roberto;Abbate, Antonio;Noviello, Stephanie
通讯作者：
Noviello, Stephanie
将白细胞介素 22 与载脂蛋白 A-I 结合可改善小鼠对乙酰氨基酚引起的肝损伤
影响因子：
12.4
作者：
Chen W;Zhang X;Fan J;Zai W;Luan J;Li Y;Wang S;Chen Q;Wang Y;Liang Y;Ju D
通讯作者：
Ju D
DOI：
10.1126/science.aad9903
发表时间：
2016-03-18
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Duffin R;O'Connor RA;Crittenden S;Forster T;Yu C;Zheng X;Smyth D;Robb CT;Rossi F;Skouras C;Tang S;Richards J;Pellicoro A;Weller RB;Breyer RM;Mole DJ;Iredale JP;Anderton SM;Narumiya S;Maizels RM;Ghazal P;Howie SE;Rossi AG;Yao C
通讯作者：
Yao C
影响因子：
7.3
作者：
Gimeno Brias S;Stack G;Stacey MA;Redwood AJ;Humphreys IR
通讯作者：
Humphreys IR
影响因子：
32.4
作者：
Antia R;Halloran ME
通讯作者：
Halloran ME