Quantification of Pulsed Operation of Rotary Left Ventricular Assist Devices with Wave Intensity Analysis.
Quantification of Pulsed Operation of Rotary Left Ventricular Assist Devices with Wave Intensity Analysis.
复制标题
通过波强度分析对旋转左心室辅助装置的脉冲操作进行量化。
DOI：
10.1097/mat.0000000000000821
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Bonde,Pramod
中科院分区：
文献类型：
--
作者：
Bouwmeester,JChristopher;Park,Jiheum;Geirsson,Arnar;Valdovinos,John;Bonde,Pramod
The current generation of left ventricular assist devices (LVADs) provides continuous flow and has the capacity to reduce aortic pulsatility, which may be related to a range of complications associated with these devices. Pulsed LVAD operation using speed modulation presents a mechanism to restore aortic pulsatility and potentially mitigate complications. We sought to investigate the interaction of axial and centrifugal LVADs with the LV and quantify the effects of continuous and pulsed LVAD operations on LV generated wave patterns under different physiologic conditions using wave intensity analysis (WIA) method. The axial LVAD created greater wave intensity associated with LV relaxation. In both LVADs, there were only minor and variable differences between the continuous and pulsed operations. The response to physiologic stress was preserved with LVAD implantation as wave intensity increased marginally with volume loading and significantly with infusion of norepinephrine. Our findings and a new approach of investigating aortic wave patterns based on WIA are expected to provide useful clinical insights to determine the ideal operation of LVADs.
