Rules of motor innervation in chick embryos with supernumerary limbs.
Rules of motor innervation in chick embryos with supernumerary limbs.
复制标题
具有多余肢体的鸡胚胎运动神经支配的规则。
DOI：
10.1002/cne.902020312
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Hollyday,M
中科院分区：
文献类型：
--
作者：
Hollyday,M
应用辣根过氧化物酶逆行追踪技术，对鸡胚移植多生肢后肌肉运动神经元的位置进行了研究。对于一个给定的肌肉，运动池的位置不同，这取决于胚胎起源的肌肉，肢体的位置沿着rostrocaudal轴的身体，肢体的方向相对于体壁。来自胚胎前肌团腹侧的肢体肌肉总是由位于内侧的运动神经元支配。来自背侧部分的肌肉始终由运动神经元在中间或远外侧的位置。这些关系是不变的肢体位置和方向的变化。这些结果表明，运动轴突可以识别和选择性地支配肌肉来源于背或腹肌肉质量。此外，脊神经支配每个肢体被确定。肢体神经丛的类型（例如，腿、坐骨或翅膀）和四肢内神经的外周分支模式也被研究，并发现由四肢控制。运动池位置的喙尾变化同样取决于肢体的位置和方向。这rostrocaudal运动池位置的变化可以解释由肢体的能力，以确定轴突的生长途径，从而限制可能的目标选择的生长axons.The肢体神经支配的过程涉及运动神经元轴突之间的相互作用具有内在的差异或特异性，和字符的肢体的局部环境中，他们成长。
The positions of motoneurons supplying individual muscles in chick embryos with grafted supernumerary limbs have been identified using retrograde transport of horseradish peroxidase. For a given muscle, motor pool location varied depending on the embryonic origin of the muscle, the position of the limb along the rostrocaudal axis of the body, and the limb's orientation with respect to the body wall. Limb muscles derived from the ventral part of the embryonic premuscle mass were always innervated by medially located motoneurons. Muscles derived from the dorsal portion were consistently innervated by motoneurons in either intermediate or far lateral positions. These relationships were invariant with changes in limb position and orientation. These findings indicate that motor axons can recognize and selectively innervate muscles derived from either dorsal or ventral muscle mass.In addition, the spinal nerves innervating each limb were identified. The type of limb plexus (e.g., crural, sciatic, or wing) and the peripheral branching patterns of the nerves within the limbs were also studied and found to be controlled by the limbs. The rostrocaudal variation in motor pool position similarly depended on the position and orientation of the limb. This rostrocaudal variation in motor pool position can be explained by the limb's ability to determine axonal outgrowth pathways and hence to constrain the possible target choices of outgrowing axons.The process of limb innervation involves interactions between motoneuron axons having intrinsic differences or specificities, and the character of the local environment of the limb into which they grow.