Intronic microRNAs: a crossroad in gene regulation
Intronic microRNAs: a crossroad in gene regulation
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DOI：
10.1042/bst20120023
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发表时间：
2012-08-01
影响因子：
3.9
通讯作者：
Gromak, Natalia
中科院分区：
文献类型：
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作者：
Gromak, Natalia
大多数由RNA Pol II（聚合酶II）转录的人类基因含有由长的非编码内含子序列分开的短外显子。除了它们在通过选择性剪接过程产生蛋白质组多样性中的作用之外，内含子序列还包含许多ncRNA（非编码RNA），参与各种基因调控过程。miRNA（microRNA）是介导mRNA转录本翻译抑制和/或降解的短ncRNA。50%至80%的miRNA在宿主mRNA基因的内含子内编码。这一观察结果表明，在miRNA生物合成和前mRNA剪接过程之间存在共调节。本文综述了这一领域的最新进展，并讨论了内含子共转录切割事件在人类基因表达调控中的可能作用。
Most human genes transcribed by RNA Pol II (polymerase II) contain short exons separated by long tracts of non-coding intronic sequences. In addition to their role in generating proteomic diversity through the process of alternative splicing, intronic sequences host many ncRNAs (non-coding RNAs), involved in various gene regulation processes. miRNAs (microRNAs) are short ncRNAs that mediate either mRNA transcript translational repression and/or degradation. Between 50 and 80 % of miRNAs are encoded within introns of host mRNA genes. This observation suggests that there is co-regulation between the miRNA biogenesis and pre-mRNA splicing processes. The present review summarizes current advances in this field and discusses possible roles for intronic co-transcriptional cleavage events in the regulation of human gene expression.