The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation.
The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation.
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DOI：
10.1083/jcb.201602089
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发表时间：
2016-06-20
期刊：
影响因子：
--
通讯作者：
Kanneganti TD
中科院分区：
文献类型：
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作者：
Sharma D;Kanneganti TD
在过去的十年中，在炎性小体在致病性和无菌损伤中的作用和调节方面取得了许多进展。炎性小体复合体包括传感器、接头和酶原原procaspase-1。炎性小体激活的功能输出包括细胞因子、IL-1β和IL-18的分泌，以及一种称为焦亡的炎性细胞死亡的诱导。最近的研究强调了这种炎症反应与基本细胞过程的交集。炎性小体激活的新调节剂和功能通常与维持体内平衡的生物功能有关。在这篇综述中，我们讨论了参与炎症小体的激活和调节的生物学过程。
Over the past decade, numerous advances have been made in the role and regulation of inflammasomes during pathogenic and sterile insults. An inflammasome complex comprises a sensor, an adaptor, and a zymogen procaspase-1. The functional output of inflammasome activation includes secretion of cytokines, IL-1β and IL-18, and induction of an inflammatory form of cell death called pyroptosis. Recent studies have highlighted the intersection of this inflammatory response with fundamental cellular processes. Novel modulators and functions of inflammasome activation conventionally associated with the maintenance of homeostatic biological functions have been uncovered. In this review, we discuss the biological processes involved in the activation and regulation of the inflammasome.