Primordial germ cells: the first cell lineage or the last cells standing?
Primordial germ cells: the first cell lineage or the last cells standing?
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DOI：
10.1242/dev.113993
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发表时间：
2015-08-15
期刊：
影响因子：
--
通讯作者：
Alberio R
中科院分区：
文献类型：
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作者：
Johnson AD;Alberio R
许多动物模型的胚胎表达抑制转录和介导早期生殖系定型的生殖系决定簇，这发生在体细胞谱系建立之前。然而，并不是所有的动物都以这种方式分离它们的生殖系。“最后一个细胞站立”模型描述了蝾螈原始生殖细胞（PGC）的发育，其中PGC由细胞外信号微环境维持，并且生殖系定型发生在原肠胚形成后。在这里，我们提出，这种“随机”模式的PGC规格是保守的脊椎动物，包括非啮齿类哺乳动物。我们假设，早期生殖系分离解放了体细胞发育的遗传调控网络，因此在动物王国中反复出现，以应对自然选择。总结：在这篇假说的文章中，约翰逊和Alberio提出，在大多数模型系统中，PGC特化的决定性机制是为了促进物种形成和进化而进化的，而不是为了维持种系。
Embryos of many animal models express germ line determinants that suppress transcription and mediate early germ line commitment, which occurs before the somatic cell lineages are established. However, not all animals segregate their germ line in this manner. The ‘last cell standing’ model describes primordial germ cell (PGC) development in axolotls, in which PGCs are maintained by an extracellular signalling niche, and germ line commitment occurs after gastrulation. Here, we propose that this ‘stochastic’ mode of PGC specification is conserved in vertebrates, including non-rodent mammals. We postulate that early germ line segregation liberates genetic regulatory networks for somatic development to evolve, and that it therefore emerged repeatedly in the animal kingdom in response to natural selection. Summary: In this Hypothesis article, Johnson and Alberio propose that the determinative mechanisms for PGC specification in most model systems evolved to promote speciation and evolvability, not to maintain the germ line.