Isolation and structure elucidation of diazaquinomycin C from a terrestrial Streptomyces sp and confirmation of the akashin structure
Isolation and structure elucidation of diazaquinomycin C from a terrestrial Streptomyces sp and confirmation of the akashin structure
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DOI：
10.1080/14786410410001704741
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发表时间：
2005-02-01
影响因子：
2.2
通讯作者：
Laatsch, H
中科院分区：
文献类型：
--
作者：
Maskey, RP;Grün-Wollny, I;Laatsch, H
从陆生链霉菌中筛选生物活性成分，分离到一种新的抗生素，命名为二氮喹霉素C（2b）。通过光谱学方法和NMR数据与2a的数据比较，发现新抗生素是二氮喹霉素A（2a）的同系物。相同的菌株还产生akashin 1a-1c。这些罕见的糖基化二氯靛衍生物中的N-O缩醛键的构型被证实为β。
In the screening of terrestrial Streptomycetes for bioactive components, a new antibiotic designated as diazaquinomycin C (2b) was isolated. The new antibiotic was found to be a homologue of diazaquinomycin A (2a) by spectroscopic methods and by comparison of the NMR data with those of 2a. The same strain additionally produced the akashins 1a-1c. The configuration of the N-O acetale bond in these rare glycosylated dichloroindigo derivatives was confirmed to be beta.