Ontogenesis of neurons producing luteinizing hormone-releasing hormone (LHRH) in the nervus terminalis of the rat.
Ontogenesis of neurons producing luteinizing hormone-releasing hormone (LHRH) in the nervus terminalis of the rat.
复制标题
大鼠终末神经中产生黄体生成素释放激素 (LHRH) 的神经元的个体发育。
DOI：
10.1002/cne.902380309
复制
发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Pfaff,DW
中科院分区：
文献类型：
--
作者：
Schwanzel-Fukuda,M;Morrell,JI;Pfaff,DW
在妊娠15天时，在大鼠终神经外周、颅内和中央部分相关的神经节细胞中首次检测到免疫反应性促黄体生成素释放激素（LHRH）。在17日龄的胎鼠中，62%的LHRH反应性神经元位于终神经节细胞中。在同一年龄，免疫反应性β-黄体生成素（β-LH）首次出现在垂体前叶的促性腺激素细胞中。在妊娠19天，在大鼠脑中观察到的LHRH反应神经元总数的31%出现在终神经中，免疫反应最早见于终板的血管器和正中隆起在胎鼠的妊娠期，终神经是LHRH的主要来源。在垂体前叶中β-LH出现之前，终神经中存在十肽，表明LHRH在该系统中对促性腺激素成熟和脑-垂体-性腺轴分化可能具有作用。
Immunoreactive luteinizing hormone‐releasing hormone (LHRH) was first detected at 15 days of gestation in ganglion cells associated with the peripheral, intracranial, and central parts of the nervus terminalis of the rat. LHRH was not detected in any other structure of the central nervous system at this age.In the 17‐day‐old fetal rat, 62% of the total LHRH‐reactive neuronal population was found in ganglion cells of the nervus terminalis. At this same age, immunoreactive beta‐luteinizing hormone (β‐LH) was first seen in gonadotropes of the anterior pituitary gland.At 19 days of gestation, 31% of the total number of LHRH‐reactive neurons observed in the rat brain was found in the nervus terminalis, and immunoreactive processes were first seen in the organum vasculosum of the lamina terminalis and in the median eminence.Our data indicate that from 15 to 19 days of gestation the nervus terminalis is a principal source of LHRH in the fetal rat. Presence of the decapeptide in the nervus terminalis prior to appearance of β‐LH in the anterior pituitary suggests a possible role for LHRH in this system on maturation of the gonadotropes and differentiation of the brain‐pituitary‐gonadal axis.