Somatomedin (insulin-like growth factors)-binding proteins. Molecular forms and regulation.
Somatomedin (insulin-like growth factors)-binding proteins. Molecular forms and regulation.
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生长调节素（胰岛素样生长因子）结合蛋白。
DOI：
10.1159/000180553
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
M. Gourmelen
中科院分区：
文献类型：
--
作者：
M. Binoux;P. Hossenlopp;Sylvie Hardouin;D. Seurin;C. Lassarre;M. Gourmelen
The insulin-like growth factor (IGF)-binding proteins present in the human serum and various biological media have been characterized by several methods: gel filtration, sucrose gradient sedimentation, polyacrylamide gel electrophoresis and chromatofocusing. Several forms have been identified with molecular weights of approximately 42,000, 39,000, 34,000, 30,000 and 24,000 daltons. Results of competitive binding studies suggest that the different forms of binding proteins have different affinities for IGF-I and IGF-II. The influence of various hormones and pathophysiological conditions on the biosynthesis of the binding proteins has been investigated.
